2,2-Difluoropropionic acid
2,2-Difluoropropionic acid (CAS 373-96-6) is a fluorinated carboxylic acid with the molecular formula C3H4F2O2 and a molecular weight of 110.06 g/mol. This compound serves as a valuable building block in organic synthesis, particularly for introducing difluoromethyl groups. Its unique structural features make it useful in the development of novel pharmaceuticals and agrochemicals. Available from Tech Serve Solutions with an assay of 97%, it is supplied for research and development purposes.
- Synonyms
- 2,2-Difluoropropanoic acidPropanoic acid, 2,2-difluoro-

Fluorinated Organic Synthesis
2,2-Difluoropropionic acid acts as a key intermediate for the synthesis of more complex fluorinated organic molecules. The presence of two fluorine atoms adjacent to the carboxylic acid group offers unique reactivity and properties for subsequent transformations.
Pharmaceutical Intermediate
This compound can be employed in the design and synthesis of pharmaceutical agents. Fluorine incorporation is a common strategy to modulate a drug candidate's metabolic stability, lipophilicity, and binding affinity.
Agrochemical Development
The difluoropropionic acid moiety can be incorporated into potential agrochemical candidates, such as herbicides or pesticides. Fluorinated compounds often exhibit enhanced biological activity and environmental persistence profiles.
Material Science Research
As a fluorinated building block, it may find applications in the development of novel materials with specific properties, such as polymers or specialty chemicals, where fluorination confers desired characteristics.
| Molecular weight | 110.06 |
|---|---|
| Empirical formula | C3H4F2O2 |
| Assay | 97% |
| Boiling point | 25-30 °C/5 mmHg |
| Melting point | 38-45 °C |

Hazard statements
- H319Causes serious eye irritation
Precautionary statements
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 65 °C / 149 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,2-Difluoropropionic acid used for?
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2,2-Difluoropropionic acid is primarily used as a building block in organic synthesis, particularly for introducing difluoromethyl groups in the development of pharmaceuticals, agrochemicals, and other specialty organic compounds.
What are the CAS number and formula for 2,2-Difluoropropionic acid?
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The CAS number for 2,2-Difluoropropionic acid is 373-96-6, and its empirical formula is C3H4F2O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,2-Difluoropropionic acid with an assay of 97%. This product is intended for research and laboratory use; TSS does not represent it as USP, BP, EP, or any other pharmacopoeia grade.
How should 2,2-Difluoropropionic acid be handled safely?
+
2,2-Difluoropropionic acid is classified as a Warning with hazard statement H319 (causes serious eye irritation). Appropriate personal protective equipment, including eyeshields, gloves, and suitable respiratory protection (e.g., type ABEK respirator filter), should be used. In case of contact with eyes, rinse cautiously with water for several minutes and seek medical advice if irritation persists (P305 + P351 + P338).
How is 2,2-Difluoropropionic acid packed, shipped, and exported?
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2,2-Difluoropropionic acid is carefully packaged to ensure safe transit and is exported globally by Tech Serve Solutions, adhering to all relevant shipping regulations for chemicals.
How can I request a sample or quote for 2,2-Difluoropropionic acid?
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To request a sample or a quote for 2,2-Difluoropropionic acid, please contact the Tech Serve Solutions sales team through our website or by phone, providing your specific requirements.
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