2,2-Dimethyl-1,3-dioxane-4,6-dione

CAS 2033-24-1C6H8O4Chemical Synthesis

2,2-Dimethyl-1,3-dioxane-4,6-dione (CAS: 2033-24-1) is an organic compound with the molecular formula C6H8O4 and a molecular weight of 144.13 g/mol. Commonly known as Meldrum's acid, it serves as a versatile building block in organic synthesis. Its reactive methylene group and cyclic ester structure make it valuable for constructing complex molecules, including heterocycles and lactones, finding utility in pharmaceutical research and fine chemical production.

IUPAC: Malonic acid cyclic isopropylidene ester,Meldrum’s acid,cycl-Isopropylidene malonate
Synonyms: Malonic acid cyclic isopropylidene esterMeldrum’s acidcycl-Isopropylidene malonate

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2,2-Dimethyl-1,3-dioxane-4,6-dione (C6H8O4) — chemical structure, CAS 2033-24-1; Chemistry, fine chemical supplied by Tech Serve Solutions

Building BlocksCarbonyl CompoundsChemical SynthesisLactonesOrganic Building Blocks

01 /Applications

Synthesis of Macrocyclic β-Keto Lactones

2,2-Dimethyl-1,3-dioxane-4,6-dione is employed in the synthesis of macrocyclic β-keto lactones, contributing to the development of novel organic compounds with potential biological activities.

Preparation of Heterocyclic Compounds

This dione is utilised in the preparation of various heterocyclic systems, such as 4-pyridyl-substituted heterocycles, which are important scaffolds in medicinal chemistry.

Indole Synthesis

It serves as a precursor in the synthesis of 2-substituted indoles, a class of compounds relevant to pharmaceutical and materials science.

Isofraxidin Production

2,2-Dimethyl-1,3-dioxane-4,6-dione has been used in the synthetic route towards isofraxidin, a naturally occurring coumarin derivative.

02 /Properties

Molecular weight	144.13
Empirical formula	C6H8O4
Assay	98%
Solubility	dioxane: soluble5%, clear to very slightly hazy, colorless to faintly yellow
Storage temperature	2-8°C
Application	2,2-Dimethyl-1,3-dioxane-4,6-dione was used in the synthesis of:• macrocyclic β-keto lactone1• 4-pyridyl-substituted heterocycles2• 2-substituted indoles3• isofraxidin.4
Melting point	92-96 °C(lit.)

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

2033-24-1

MDL number

MFCD00006638

PubChem substance

24852618

Beilstein registry

117310

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 2,2-Dimethyl-1,3-dioxane-4,6-dione used for?

It is a versatile building block in organic synthesis, notably used in the preparation of macrocyclic β-keto lactones, 4-pyridyl-substituted heterocycles, 2-substituted indoles, and isofraxidin.

What is the CAS number and formula for 2,2-Dimethyl-1,3-dioxane-4,6-dione?

The CAS number is 2033-24-1 and the empirical formula is C6H8O4.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 2,2-Dimethyl-1,3-dioxane-4,6-dione with an assay of 98%. This product is suitable for research and technical applications. TSS does not represent this product as USP, BP, EP, or other pharmacopoeial grades unless explicitly stated.

What are the safety considerations when handling 2,2-Dimethyl-1,3-dioxane-4,6-dione?

This compound requires careful handling. Appropriate personal protective equipment, including eyeshields and gloves, should be worn. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Refer to the safety data sheet for comprehensive handling guidelines. It has a WGK Germany rating of 3.

How is 2,2-Dimethyl-1,3-dioxane-4,6-dione typically stored and shipped?

It is recommended to store 2,2-Dimethyl-1,3-dioxane-4,6-dione at 2-8°C. Tech Serve Solutions exports fine chemicals globally, adhering to all relevant shipping and packaging regulations.

How can I request a sample or quote for 2,2-Dimethyl-1,3-dioxane-4,6-dione?

To request a sample or a quotation, please contact our sales team through the website or by phone. Please specify the quantity required and your delivery location.