Methyl pentafluoropropionate
Methyl pentafluoropropionate (CAS: 378-75-6), with the chemical formula C2F5CO2CH3 and a molecular weight of 178.06 g/mol, is a fluorinated ester. It serves as a versatile building block and reagent in organic synthesis. This compound is particularly useful in the introduction of fluorinated moieties into various organic molecules, finding applications in materials science and pharmaceutical research. Its properties make it a valuable intermediate for specialised chemical applications.

Organic Synthesis Intermediate
Methyl pentafluoropropionate is a key intermediate in the synthesis of complex organic molecules. Its reactive ester group and the presence of a pentafluoroethyl moiety allow for diverse chemical transformations.
Fluorinated Building Block
This compound is employed as a building block for introducing the pentafluoroethyl group into target molecules. This is crucial in the development of novel fluorinated materials and pharmaceuticals with enhanced properties.
Research and Development
Utilised in R&D settings for exploring new synthetic pathways and developing novel compounds. Its specific reactivity profile supports investigation into fluorochemical applications.
| Molecular weight | 178.06 |
|---|---|
| Linear formula | C2F5CO2CH3 |
| Assay | 99% |
| Boiling point | 61 °C/739 mmHg(lit.) |
| Density | 1.393 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.288(lit.) |


Hazard statements
- H225Highly flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 6 °C / 42.8 °F |
| Transport (UN / ADR) | UN 3272 3 / PGII |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | F,Xi |
| Risk statements (R) | 11-36/37/38 |
| Safety statements (S) | 16-26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl pentafluoropropionate used for?
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Methyl pentafluoropropionate is used as a building block and intermediate in organic synthesis, particularly for introducing fluorinated moieties into organic molecules for applications in materials science and pharmaceutical research.
What is the CAS number and formula for Methyl pentafluoropropionate?
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The CAS number is 378-75-6, and the chemical formula is C2F5CO2CH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methyl pentafluoropropionate with an assay of 99%. This product is supplied for research and laboratory purposes and is not represented as USP, BP, EP, or other pharmacopoeia grades.
How should Methyl pentafluoropropionate be handled safely?
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Methyl pentafluoropropionate is a flammable liquid and vapour (H225), causes skin irritation (H315), and causes serious eye irritation (H319), and may cause respiratory irritation (H335). Handle with appropriate personal protective equipment, including safety eyeshields, face shields, chemical-resistant gloves, and ensure adequate ventilation. Refer to the Safety Data Sheet for detailed handling procedures.
How is Methyl pentafluoropropionate packed, shipped, and exported?
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Methyl pentafluoropropionate is packed in accordance with safety regulations for flammable liquids. Tech Serve Solutions, a global supplier since 1998, can arrange for its export worldwide, adhering to all international shipping and customs requirements.
How can I request a sample or quote for Methyl pentafluoropropionate?
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To request a sample or a quote, please contact our sales team via the website or direct inquiry, providing your specific requirements.
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