Tetrodotoxin
Tetrodotoxin (CAS: 4368-28-9, C11H17N3O8) is a potent neurotoxin with a molecular weight of 319.27 g/mol. It is known for its selective blockade of voltage-gated sodium channels. This highly pure white powder is valuable in biological research for investigating ion channel function and cellular signaling pathways. Its applications are primarily in scientific research settings, focusing on neurobiology and ion channel studies.
- IUPAC
- Fugu poison,Maculotoxin,TTX,Tarichatoxin
- Synonyms
- Fugu poisonMaculotoxinTTXTarichatoxin
HPLC-Based Biotoxin Analysis
Tetrodotoxin serves as a standard in High-Performance Liquid Chromatography (HPLC) for the quantitative analysis of biotoxins derived from organisms such as <i>P. punctata</i> tentacles.
Neuroscience Research
Utilised in studies examining the effects of sodium channel blockade on neuronal activity, including its impact on transient calcium currents in rat hippocampal interneurons.
Ion Channel Research
Applied to investigate the structure and function of voltage-gated sodium channels and their role in cellular electrophysiology.
| Molecular weight | 319.27 |
|---|---|
| Empirical formula | C11H17N3O8 |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white |
| Solubility | dilute citrate or acetate buffer: soluble1 mg/mL (dissolve at pH 4-5. Aqueous solutions, pH 4-5, are stable if stored frozen.)strong acid or alkaline solutions: unstable (destroyed by boiling at pH 2.) |
| pH | 4.8 |
| Storage temperature | 2-8°C |
| Application | Tetrodotoxin has been used as standard during HPLC-based analysis of biotoxins from P. punctata tentacles whole crude extract (PHY-N)1. Tetrodotoxin has also been used to study its effects on low-threshold transient (LTT) Ca2+ currents in rat hippocampal interneurons2. |
Hazard statements
- H300Fatal if swallowed
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P264Wash thoroughly after handling
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P301IF SWALLOWED
- P302IF ON SKIN
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3462 6.1 / PGI |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 26/27/28 |
| Safety statements (S) | 22-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | rat ... Scnn1g(24768) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tetrodotoxin used for?
+
Tetrodotoxin is primarily used as a standard in analytical chemistry, particularly for HPLC-based biotoxin analysis, and in neuroscience and ion channel research to study the effects on voltage-gated sodium channels and neuronal activity.
What is the CAS number and formula for Tetrodotoxin?
+
The CAS number is 4368-28-9 and the empirical formula is C11H17N3O8.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tetrodotoxin with a minimum purity of ≥98% (HPLC). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should Tetrodotoxin be handled safely?
+
Tetrodotoxin is extremely toxic and requires careful handling. It is classified as Danger with hazard statements H300 +H310 + H330, indicating it is fatal if swallowed, in contact with skin, or if inhaled. Appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection (type N100 or P3 filters), is essential. Handle in a well-ventilated area or fume hood.
How is Tetrodotoxin packed and exported?
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Tetrodotoxin is typically supplied as a white powder and stored at 2-8°C. As a specialist global supplier, Tech Serve Solutions adheres to all regulations for the safe packing and international export of hazardous chemicals.
How can I request a sample or quote for Tetrodotoxin?
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To request a sample or obtain a quote for Tetrodotoxin, please contact our sales team through the website or by calling our dedicated customer service line.
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