2,2-Difluoro-2-(fluorosulfonyl)acetic acid
2,2-Difluoro-2-(fluorosulfonyl)acetic acid (CAS 1717-59-5), with the linear formula FSO₂CF₂CO₂H, is a specialised organic fluorinated building block. This compound, featuring both a fluorosulfonyl and a difluoroacetic acid moiety, is primarily utilised in advanced chemical synthesis. Its unique structure makes it a valuable reagent in reactions requiring the introduction of difluoromethyl groups or related fluorinated functionalities, contributing to the development of novel materials and pharmaceuticals.
- IUPAC
- (Fluorosulfonyl)difluoroacetic acid
- Synonyms
- FSO2CF2CO2H
Difluorocarbene Precursor
This compound serves as a precursor for silyl fluorosulfonyldifluoroacetate, a highly effective reagent for the cyclopropanation of alkenes, enabling precise and efficient carbon-carbon bond formation.
Free Radical Fluoroalkylation
It is employed in regio- and stereoselective free radical fluoroalkylation reactions of terminal alkenes and alkynes, utilising iododifluoromethanesulfonamides as key intermediates.
Fluorinated Building Block
As a versatile fluorinated building block, it is instrumental in the synthesis of complex organic molecules, offering a route to incorporate difluorinated moieties.
| Molecular weight | 178.09 |
|---|---|
| Linear formula | FSO2CF2CO2H |
| Assay | 97% |
| Boiling point | 153 °C(lit.) |
| Density | 1.723 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.36(lit.) |
| Application | Used in the preparation of silyl fluorosulfonyldifluoroacetate as new highly efficient difluorocarbene reagent for cyclopropanation of alkenes1,2Regio- and stereoselective free radical fluoroalkylation of terminal alkenes and alkynes with iododifluoromethanesulfonamides3 |
Hazard statements
- H300Fatal if swallowed
- H310Fatal in contact with skin
- H314Causes severe skin burns and eye damage
Precautionary statements
- P264Wash thoroughly after handling
- P280Wear protective gloves, clothing and eye/face protection
- P302IF ON SKIN
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Flash point | 110 °C / 230 °F |
| Transport (UN / ADR) | UN 2927 8(6.1) / PGI |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+,C |
| Risk statements (R) | 27/28-35 |
| Safety statements (S) | 28-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,2-Difluoro-2-(fluorosulfonyl)acetic acid used for?
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It is used in chemical synthesis, primarily as a precursor for difluorocarbene reagents in cyclopropanation reactions and for free radical fluoroalkylation of alkenes and alkynes.
What is the CAS number and formula for 2,2-Difluoro-2-(fluorosulfonyl)acetic acid?
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The CAS number is 1717-59-5, and its linear formula is FSO₂CF₂CO₂H.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,2-Difluoro-2-(fluorosulfonyl)acetic acid with an assay of 97%. This product is not represented as USP, BP, or EP grade.
What are the safety considerations for handling this chemical?
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This compound is classified as Dangerous, with hazards including acute toxicity (oral and dermal) and severe skin burns and eye damage (H300-H310-H314). Appropriate personal protective equipment, including eyeshields, face shields, and chemical-resistant gloves, is essential. Respiratory protection is also recommended.
Is this chemical available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 2,2-Difluoro-2-(fluorosulfonyl)acetic acid.
How can I request a sample or quote?
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Please contact the Tech Serve Solutions sales team through our website or by phone to request a sample or a quotation for 2,2-Difluoro-2-(fluorosulfonyl)acetic acid.
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