Indazole-6-boronic acid
Indazole-6-boronic acid (CAS: 885068-10-0; Formula: C7H7BN2O2; MW: 161.95 g/mol) is a versatile heteroaryl boronic acid derivative. This compound serves as a key building block in organic synthesis, particularly in the preparation of complex molecular architectures. Its utility is demonstrated in the synthesis of various biologically active compounds, including enzyme inhibitors and kinase modulators, making it a valuable reagent for pharmaceutical research and development.
Preparation of Hydroxysteroid Dehydrogenase Inhibitors
Indazole-6-boronic acid is utilised as a reactant in synthesising bicyclic hydroxyphenylmethanone derivatives. These compounds have shown potential as inhibitors of hydroxysteroid dehydrogenase, a target in various therapeutic areas.
Synthesis of Farnesyl Pyrophosphate Synthase Inhibitors
This boronic acid derivative is employed in the preparation of bisphosphonate inhibitors. These molecules target human farnesyl pyrophosphate synthase, an enzyme relevant in bone resorption and cancer therapies.
Development of PKC-ζ Inhibitors
Indazole-6-boronic acid serves as a precursor for indazolyl benzoimidazole compounds. Research indicates these structures can act as inhibitors of protein kinase C zeta (PKC-ζ), a signalling molecule involved in various cellular processes.
Generation of Kinase Inhibitory Pyrazolopyrimidinamines
The compound is a reactant in the synthesis of pyrazolopyrimidinamine derivatives. These molecules are investigated for their inhibitory activity against tyrosine and phosphoinositide kinases, crucial targets in oncology and inflammatory diseases.
| Molecular weight | 161.95 |
|---|---|
| Empirical formula | C7H7BN2O2 |
| Storage temperature | 2-8°C |
| Application | Reactant for preparation of:• Bicyclic hydroxyphenylmethanone derivatives as hydroxysteroid dehydrogenase inhibitors1• Bisphosphonate inhibitors of human farnesyl pyrophosphate synthase2• Indazolyl benzoimidazoles as PKC-ζ inhibitors3• Pyrazolopyrimidinamine derivatives and their tyrosine and phosphinositide kinase inhibitory activity4 |
| Melting point | 112-117 °C |
Hazard statements
- H302Harmful if swallowed
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
| Safety statements (S) | 22-24/25 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Indazole-6-boronic acid used for?
+
Indazole-6-boronic acid is primarily used as a reactant in organic synthesis for preparing complex molecules, including enzyme and kinase inhibitors relevant to pharmaceutical research.
What is the CAS number and chemical formula for Indazole-6-boronic acid?
+
The CAS number for Indazole-6-boronic acid is 885068-10-0, and its chemical formula is C7H7BN2O2.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies Indazole-6-boronic acid for research and laboratory use. The specific assay and purity are detailed in the product's Certificate of Analysis. We do not represent this product as USP, BP, or EP grade.
How should Indazole-6-boronic acid be handled?
+
Indazole-6-boronic acid is classified as harmful if swallowed (H302). Handle with appropriate personal protective equipment, avoid ingestion, and ensure adequate ventilation. Refer to the Safety Data Sheet for comprehensive handling information.
How is Indazole-6-boronic acid shipped and exported?
+
Indazole-6-boronic acid is carefully packed to ensure safe transit and is available for global export by Tech Serve Solutions, adhering to all relevant shipping regulations.
How can I request a quote or sample for Indazole-6-boronic acid?
+
To request a quote or a sample of Indazole-6-boronic acid, please contact our sales team through the website or by phone, providing your contact details and requirements.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis