2,2,2-Trifluoroethanesulfonyl chloride
2,2,2-Trifluoroethanesulfonyl chloride (CAS: 1648-99-3), with the linear formula CF₃CH₂SO₂Cl and a molecular weight of 182.55 g/mol, is a chemical reagent. It is primarily utilized in organic synthesis as a trifluoroethylsulfonylating agent for protecting groups and in the derivatization of various molecules.
- IUPAC
- Tresyl chloride
- Synonyms
- 1648-99-3CF3CH2SO2ClTresyl chloride
Protecting Group Chemistry
2,2,2-Trifluoroethanesulfonyl chloride is employed to introduce the trifluoroethylsulfonyl (tresyl) group, which serves as a robust protecting group for alcohols and amines in complex organic syntheses.
Derivatization Reagent
This compound can be used for the derivatization of functional groups, enhancing their detectability or altering their properties for analytical or synthetic purposes.
Organic Synthesis
As a versatile synthetic reagent, it facilitates the formation of new carbon-sulfur bonds and is valuable in the construction of diverse organic molecules.
| Molecular weight | 182.55 |
|---|---|
| Linear formula | CF3CH2SO2Cl |
| Assay | 99% |
| Boiling point | 140-141 °C(lit.)64-67 °C/45 mmHg(lit.) |
| Density | 1.651 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.388(lit.) |
| Storage temperature | 2-8°C |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 72 °C / 161.6 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,2,2-Trifluoroethanesulfonyl chloride used for?
+
2,2,2-Trifluoroethanesulfonyl chloride is primarily used in organic synthesis as a trifluoroethylsulfonylating agent for introducing protecting groups and for derivatizing various molecules.
What is the CAS number and chemical formula for 2,2,2-Trifluoroethanesulfonyl chloride?
+
The CAS number is 1648-99-3 and the linear formula is CF₃CH₂SO₂Cl.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 2,2,2-Trifluoroethanesulfonyl chloride with a minimum purity of 99%. TSS does not represent this product as USP, BP, or EP grade.
How should 2,2,2-Trifluoroethanesulfonyl chloride be handled safely?
+
2,2,2-Trifluoroethanesulfonyl chloride is a corrosive substance (H314) that causes severe skin burns and eye damage. It requires handling with full protective equipment, including face shields, goggles, gloves, and appropriate respiratory protection. Refer to the Safety Data Sheet for detailed handling procedures.
Is 2,2,2-Trifluoroethanesulfonyl chloride a controlled substance?
+
The provided data does not indicate that 2,2,2-Trifluoroethanesulfonyl chloride is a controlled substance.
How is 2,2,2-Trifluoroethanesulfonyl chloride packed and shipped?
+
2,2,2-Trifluoroethanesulfonyl chloride is shipped as UN 3265, Class 8, Packing Group II, indicating it is a corrosive liquid. Specific packaging details are available upon request.
How can I request a quote or sample for 2,2,2-Trifluoroethanesulfonyl chloride?
+
To request a quote or sample, please contact Tech Serve Solutions directly through our website or by phone, providing the product name and CAS number.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis