2,2,2-Trifluoro-3′-(trifluoromethyl)acetophenone
2,2,2-Trifluoro-3′-(trifluoromethyl)acetophenone (CAS 721-37-9) is a fluorinated aromatic ketone with the molecular formula CF3C6H4COCF3 and a molecular weight of 242.12 g/mol. This compound serves as a valuable building block in organic synthesis. Its unique structure, featuring two trifluoromethyl groups, makes it useful for introducing fluorine into more complex molecules, particularly in the development of pharmaceuticals and advanced materials.
- Synonyms
- 721-37-9CF3C6H4COCF3
Organic Synthesis Intermediate
This fluorinated ketone is a key intermediate in the synthesis of various organic compounds. It allows for the regioselective introduction of trifluoromethyl groups, which can significantly alter the properties of target molecules.
Pharmaceutical Research
The incorporation of trifluoromethyl groups is a common strategy in medicinal chemistry to enhance lipophilicity, metabolic stability, and binding affinity of drug candidates. This compound is utilized in the early stages of pharmaceutical research and development.
Materials Science
Fluorinated organic compounds often exhibit unique electronic and physical properties, making them of interest in materials science. 2,2,2-Trifluoro-3′-(trifluoromethyl)acetophenone can be used in the synthesis of novel fluorinated polymers or specialty materials.
| Molecular weight | 242.12 |
|---|---|
| Linear formula | CF3C6H4COCF3 |
| Assay | 98% |
| Boiling point | 65-67 °C/24 mmHg(lit.) |
| Density | 1.418 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.415(lit.) |
Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 59 °C / 138.2 °F |
| Transport (UN / ADR) | UN 1224C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,2,2-Trifluoro-3′-(trifluoromethyl)acetophenone primarily used for?
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It is primarily used as a building block in organic synthesis, particularly for introducing trifluoromethyl groups into complex molecules relevant to pharmaceutical research and materials science.
What is the CAS number and chemical formula for this compound?
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The CAS number is 721-37-9 and the linear formula is CF3C6H4COCF3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound at a purity of 98% assay. This product is not represented as USP, BP, EP, or pharmaceutical grade.
How should 2,2,2-Trifluoro-3′-(trifluoromethyl)acetophenone be handled safely?
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This compound is a flammable liquid and vapour (H226) and can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Use appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, and handle in a well-ventilated area. Refer to the safety data sheet for full details.
Is this chemical controlled or scheduled?
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The provided data does not indicate that this chemical is a controlled or scheduled substance.
How are your chemicals packed, shipped, and exported?
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Tech Serve Solutions expertly packs, ships, and exports fine chemicals globally, adhering to all necessary international regulations for hazardous materials transportation.
How can I request a quote or sample?
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To request a quote or sample, please contact our sales team through the website or by phone, providing the product name and CAS number (721-37-9).
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