2,2,2-Trifluoroacetophenone
2,2,2-Trifluoroacetophenone (CAS: 434-45-7), with the molecular formula C7H5F3O and a molecular weight of 174.12 g/mol, is a fluorinated ketone. This compound serves as a valuable building block in organic synthesis. Its notable applications include the creation of advanced fluorinated polymers, contributing to materials with enhanced thermal stability and desirable film-forming characteristics.
- IUPAC
- α,α,α-Trifluoroacetophenone,Phenyl trifluoromethyl ketone
- Synonyms
- 434-45-7CF3COC6H5α,α,α-TrifluoroacetophenonePhenyl trifluoromethyl ketone

Fluorinated Polymer Synthesis
2,2,2-Trifluoroacetophenone is utilized in the synthesis of novel fluorinated polymers. These polymers are known for their high average molecular weights, excellent thermal stability, and good film-forming properties.
Organic Synthesis Intermediate
As a trifluoromethyl ketone, this compound acts as a versatile intermediate in various organic synthesis pathways. It enables the introduction of the trifluoromethyl group into complex molecules.
Building Block for Specialty Chemicals
This chemical serves as a foundational building block for the development of other specialised chemical compounds. Its unique structure lends itself to the creation of materials with specific performance attributes.
| Molecular weight | 174.12 |
|---|---|
| Linear formula | CF3COC6H5 |
| Assay | 99% |
| Boiling point | 165-166 °C(lit.)46-48 °C/14 mmHg(lit.) |
| Density | 1.24 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.458(lit.) |
| Application | 2,2,2-Trifluoroacetophenone was used in the synthesis of new fluorinated polymers, having high average molecular weight, high thermal stability and good film-forming properties1. |


Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 41 °C / 105.8 °F |
| Transport (UN / ADR) | UN 1224C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,2,2-Trifluoroacetophenone used for?
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2,2,2-Trifluoroacetophenone is used as a building block in organic synthesis, particularly for creating fluorinated polymers with high thermal stability and good film-forming properties.
What is the CAS number and formula for 2,2,2-Trifluoroacetophenone?
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The CAS number is 434-45-7 and the linear formula is CF3COC6H5.
What grade and purity does Tech Serve Solutions supply for 2,2,2-Trifluoroacetophenone?
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Tech Serve Solutions supplies 2,2,2-Trifluoroacetophenone with a purity of 99%. This is a technical or research grade material, and TSS does not represent it as USP, BP, or EP grade.
How should 2,2,2-Trifluoroacetophenone be handled safely?
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2,2,2-Trifluoroacetophenone is a flammable liquid and vapour (H226), and causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, in a well-ventilated area. Refer to the Safety Data Sheet for full details.
Is 2,2,2-Trifluoroacetophenone available for export and how is it shipped?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals. 2,2,2-Trifluoroacetophenone is classified as UN 1224C 3 / PGIII for transport.
How can I request a quote or sample of 2,2,2-Trifluoroacetophenone?
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To request a quote or sample, please contact our sales team through the website or by calling our direct line. Provide the product name and CAS number (434-45-7) for prompt service.
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