Indazole-4-boronic acid hydrochloride
Indazole-4-boronic acid hydrochloride (CAS: 1023595-17-6) is a key organoboron compound with the molecular formula C7H8BClN2O2 and a molecular weight of 198.41 g/mol. This heteroaryl boronic acid derivative serves as a valuable reactant in organic synthesis, particularly in the preparation of complex heterocyclic compounds. Its applications are focused on the development of novel therapeutic agents, contributing to advancements in medicinal chemistry and pharmaceutical research.
- IUPAC
- Indazol-4-ylboronic acid hydrochloride
- Synonyms
- Indazol-4-ylboronic acid hydrochloride
Synthesis of Kinase Inhibitors
This compound is a crucial reactant in the preparation of trisubstituted pyrimidines investigated as potent phosphatidylinositol 3-kinase (PI3K) inhibitors. These molecules hold promise for targeted cancer therapies.
Development of Enzyme Inhibitors
It is employed in the synthesis of bisphosphonate compounds designed to inhibit human farnesyl pyrophosphate synthase (FPPS). Such inhibitors are relevant in treating bone diseases and certain cancers.
Heterocyclic Chemistry
As a heteroaryl boronic acid, it is a versatile building block for constructing complex nitrogen-containing heterocyclic systems, widely applicable in drug discovery.
| Molecular weight | 198.41 |
|---|---|
| Empirical formula | C7H8BClN2O2 |
| Storage temperature | 2-8°C |
| Application | Reactant for:• Preparation of trisubstituted pyrimidines as phosphatidylinositol 3-kinase inhibitors1• Preparation of bisphosphonate inhibitors of human farnesyl pyrophosphate synthase2 |
| Melting point | 173-177 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Indazole-4-boronic acid hydrochloride used for?
+
Indazole-4-boronic acid hydrochloride (CAS: 1023595-17-6) is used as a reactant in organic synthesis, notably for preparing trisubstituted pyrimidines as phosphatidylinositol 3-kinase inhibitors and for synthesising bisphosphonate inhibitors of human farnesyl pyrophosphate synthase.
What is the CAS number and molecular formula for Indazole-4-boronic acid hydrochloride?
+
The CAS number is 1023595-17-6, and the molecular formula is C7H8BClN2O2.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies this chemical for research and development purposes. The specific assay and purity information is available on the product's Certificate of Analysis. We do not represent this product as meeting USP, BP, or EP pharmacopoeia standards.
How should Indazole-4-boronic acid hydrochloride be handled?
+
Indazole-4-boronic acid hydrochloride is classified with GHS07 (Warning) and carries hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Handle with appropriate personal protective equipment in a well-ventilated area. Avoid contact with skin, eyes, and clothing. For full safety details, consult the Safety Data Sheet.
How is this chemical stored and shipped?
+
This compound is typically stored under refrigeration at 2-8°C. TSS ensures all products are carefully packaged and exported in compliance with international shipping regulations for chemical substances.
How can I request a sample or quote?
+
To request a sample or a formal quotation, please contact our sales department via the website or by calling our dedicated customer service line. Please reference the product name and CAS number (1023595-17-6).
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis