(R)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol tert-butyldimethylsilyl ether
(R)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol tert-butyldimethylsilyl ether (CAS 1146629-74-4) is a complex organosilicon compound with the molecular formula C27H29F12NOSi and a molecular weight of 639.59 g/mol. This chiral building block features a pyrrolidine core and heavily fluorinated phenyl groups. It is primarily utilised in advanced chemical synthesis as a versatile intermediate and research chemical, particularly in areas requiring stereochemical control.
- IUPAC
- (R)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]prolinol tert-butyldimethylsilyl ether,(R)-2-{Bis[3,5-bis(trifluoromethyl)phenyl](tert-butyldimethylsilanyloxy)methyl}pyrrolidine
- Synonyms
- 1146629-74-4(R)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]prolinol tert-butyldimethylsilyl ether(R)-2-{Bis[3,5-bis(trifluoromethyl)phenyl](tert-butyldimethylsilanyloxy)methyl}pyrrolidine
![(R)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol tert-butyldimethylsilyl ether (C27H29F12NOSi) — chemical structure, CAS 1146629-74-4; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F1146629-74-4.png&w=3840&q=75)
Chiral Synthesis Intermediate
This compound serves as a valuable chiral building block in asymmetric synthesis. Its defined stereochemistry allows for the construction of complex molecules with specific enantiomeric forms, crucial in pharmaceutical and fine chemical development.
Fluorinated Compound Precursor
The presence of multiple trifluoromethyl groups makes it a useful precursor for synthesising other highly fluorinated organic molecules. These fluorinated compounds often exhibit unique chemical and physical properties beneficial in materials science and medicinal chemistry.
Specialty Reagent in Organic Chemistry
As a research chemical, it can be employed in specialised organic transformations. Its unique structural features may enable novel reaction pathways or improve the efficiency of existing synthetic methods in academic and industrial research settings.
| Molecular weight | 639.59 |
|---|---|
| Empirical formula | C27H29F12NOSi |
| Assay | ≥96.0% (HPLC) |
| Optical activity | [α]/D -3.5±0.5°, c = 1 in chloroform |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
- H413May cause long-lasting harmful effects to aquatic life
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | C,N |
| Risk statements (R) | 22-37/38-41-54 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol tert-butyldimethylsilyl ether used for?
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This compound is primarily used as a chiral building block and intermediate in advanced organic synthesis, particularly for constructing complex, stereochemically defined molecules and other highly fluorinated organic compounds.
What are the CAS number and formula for this chemical?
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The CAS number is 1146629-74-4, and the empirical formula is C27H29F12NOSi.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with a purity of ≥96.0% as determined by HPLC. We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should (R)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol tert-butyldimethylsilyl ether be handled?
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This compound is classified as Danger and can cause serious eye damage, is harmful if swallowed, causes skin irritation, and may cause respiratory irritation. Handle with appropriate personal protective equipment, including gloves, eye protection, and ensure adequate ventilation. Avoid breathing dust/fume/gas/mist/vapours/spray. In case of contact with eyes, rinse cautiously with water for several minutes, removing contact lenses if present and easy to do. Continue rinsing.
Is this chemical suitable for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including this product. We handle all necessary export procedures.
How can I request a sample or quote?
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To request a sample or a quote, please contact our sales team through the website or by phone. Provide the product name or CAS number (1146629-74-4) for a prompt response.
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