(R)-(+)-4-Chloro-3-hydroxybutyronitrile
(R)-(+)-4-Chloro-3-hydroxybutyronitrile (CAS: 84367-31-7) is a chiral building block with the linear formula ClCH₂CH(OH)CH₂CN and a molecular weight of 119.55 g/mol. This organic compound serves as a valuable synthon in asymmetric synthesis. It has been documented for its use in the preparation of important molecules such as (-)-Carnitine and (-)-γ-amino-β-hydroxybutyric acid, demonstrating its utility in complex organic synthesis pathways.
Chiral Synthesis of Pharmaceuticals
This compound is a key intermediate in the synthesis of enantiomerically pure pharmaceuticals. Its chiral nature allows for the stereoselective construction of complex molecular architectures required for drug development, such as in the preparation of (-)-Carnitine.
Preparation of Bioactive Molecules
It serves as a synthon for biologically active compounds. Its application in the synthesis of (-)-γ-amino-β-hydroxybutyric acid highlights its role in accessing molecules relevant to neuroscience and metabolic research.
Organic Building Block
As a versatile organic building block, it can be employed in various chemical synthesis strategies. The presence of nitrile, hydroxyl, and chloride functionalities offers multiple reaction sites for further derivatisation.
| Molecular weight | 119.55 |
|---|---|
| Linear formula | ClCH2CH(OH)CH2CN |
| Assay | 97% |
| Boiling point | 110 °C/1 mmHg(lit.) |
| Density | 1.250 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.474(lit.) |
| Optical activity | [α]25/D +11.0°, neat |
| Application | (-)-Carnitine and (-)-γ-amino-β-hydroxybutyric acid have been prepared using this synthon.1 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(+)-4-Chloro-3-hydroxybutyronitrile used for?
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This compound is primarily used as a chiral building block and synthon in asymmetric synthesis, notably in the preparation of (-)-Carnitine and (-)-γ-amino-β-hydroxybutyric acid.
What is the CAS number and formula for (R)-(+)-4-Chloro-3-hydroxybutyronitrile?
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The CAS number is 84367-31-7 and the linear formula is ClCH₂CH(OH)CH₂CN.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (R)-(+)-4-Chloro-3-hydroxybutyronitrile with a minimum assay of 97%. This product is supplied for research and chemical synthesis purposes and is not represented as USP, BP, EP, or pharmacopoeia grade.
What are the safety considerations for handling (R)-(+)-4-Chloro-3-hydroxybutyronitrile?
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This compound is classified as a Warning substance, causing skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields and suitable gloves, should be worn, and handling should occur in a well-ventilated area or fume hood.
How is (R)-(+)-4-Chloro-3-hydroxybutyronitrile packed, shipped, and exported?
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As a global supplier and exporter, Tech Serve Solutions ensures that all chemicals are packed, shipped, and exported in compliance with relevant international regulations to maintain product integrity and safety during transit.
How can I request a sample or quote for (R)-(+)-4-Chloro-3-hydroxybutyronitrile?
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To request a sample or obtain a quote, please visit the Tech Serve Solutions website or contact our sales team directly with your specific requirements.
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