(R)-(–)-4,12-Bis(diphenylphosphino)-[2.2]-paracyclophane
(R)-(–)-4,12-Bis(diphenylphosphino)-[2.2]-paracyclophane (CAS: 364732-88-7), a chiral phosphine ligand with a molecular weight of 576.65 g/mol. This compound is primarily utilised as an efficient ligand in asymmetric hydrogenation reactions. It is particularly effective for the stereoselective reduction of dehydroamino acid methyl esters and ketones, playing a crucial role in the synthesis of enantiomerically pure compounds.
- IUPAC
- (R)-Phanephos
- Synonyms
- (R)-Phanephos
![(R)-(–)-4,12-Bis(diphenylphosphino)-[2.2]-paracyclophane (C40H34P2) — chemical structure, CAS 364732-88-7; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F364732-88-7.png&w=3840&q=75)
Asymmetric Hydrogenation
Serves as a highly effective chiral ligand for the asymmetric hydrogenation of various substrates, including dehydroamino acids and ketones. It enables the synthesis of enantiomerically enriched products with high selectivity.
Chiral Catalyst Development
A key component in the development of chiral catalytic systems for asymmetric synthesis. Its unique structure promotes high enantioselectivity in metal-catalyzed transformations.
Pharmaceutical Intermediate Synthesis
Facilitates the stereoselective synthesis of crucial chiral building blocks and intermediates required in the pharmaceutical industry. This is vital for the production of enantiopure active pharmaceutical ingredients (APIs).
| Molecular weight | 576.65 |
|---|---|
| Empirical formula | C40H34P2 |
| Assay | 96% |
| Optical activity | [α]/D -34±4°, c = 1 in chloroform |
| Application | Efficient ligand for asymmetric hydrogentation of dehydroamino acids, methyl esters and keytones.1,2 |
| Melting point | 222-226 °C |
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(–)-4,12-Bis(diphenylphosphino)-[2.2]-paracyclophane used for?
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This compound is an efficient chiral ligand for asymmetric hydrogenation reactions, particularly for dehydroamino acid methyl esters and ketones.
What are the CAS number and formula for (R)-(–)-4,12-Bis(diphenylphosphino)-[2.2]-paracyclophane?
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The CAS number is 364732-88-7 and the empirical formula is C40H34P2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical at an assay of 96%. It is not represented as USP, BP, EP, or other pharmacopoeia grades.
What are the safety and handling precautions for this compound?
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Handling requires a dust mask type N95 (US), eyeshields, and gloves. It is classified as an irritant (Xi) with risk statement R37 (Irritating to respiratory system). Appropriate ventilation is recommended.
How is (R)-(–)-4,12-Bis(diphenylphosphino)-[2.2]-paracyclophane packed, shipped, and exported?
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Tech Serve Solutions offers professional packing, shipping, and export services for this chemical worldwide.
How can I request a sample or quote for (R)-(–)-4,12-Bis(diphenylphosphino)-[2.2]-paracyclophane?
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To request a sample or quote, please contact our sales team via the website or provide your requirements through the product page.
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