(R)-(–)-4,12-Bis[di(3,5-xylyl)phosphino]-[2.2]-paracyclophane
(R)-(–)-4,12-Bis[di(3,5-xylyl)phosphino]-[2.2]-paracyclophane (CAS: 325168-89-6) is a chiral ligand with the molecular formula C48H50P2 and a molecular weight of 688.86 g/mol. It is primarily utilised as an effective ligand in asymmetric hydrogenation reactions, particularly for substrates such as dehydroamino acids, methyl esters, and ketones. Tech Serve Solutions supplies this compound at an assay of 97% for research and chemical synthesis purposes.
- IUPAC
- (R)-Xylyl-PHANEPhos,(R)-5,11-Bis(3,5-xylylphosphino)tricyclo[8.2.2.24,7]hexadeca-hexaene
- Synonyms
- 325168-89-6C48H50P2
![(R)-(–)-4,12-Bis[di(3,5-xylyl)phosphino]-[2.2]-paracyclophane (C48H50P2) — chemical structure, CAS 325168-89-6; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F325168-89-6.png&w=3840&q=75)
Asymmetric Hydrogenation
This paracyclophane derivative serves as an efficient chiral ligand in asymmetric hydrogenation. It is effective for the stereoselective reduction of dehydroamino acids, methyl esters, and various ketones, enabling the synthesis of enantiomerically enriched products.
Chiral Catalysis
As a P-Phos ligand, it plays a crucial role in chiral catalysis. Its specific structure facilitates high enantioselectivity in catalytic processes, making it valuable for the synthesis of chiral molecules in pharmaceutical and fine chemical industries.
Organic Synthesis
The compound is a key reagent in advanced organic synthesis. Its application is critical for introducing chirality into molecules, supporting complex synthetic routes where stereochemical control is paramount.
| Molecular weight | 688.86 |
|---|---|
| Empirical formula | C48H50P2 |
| Assay | 97% |
| Optical activity | [α]22/D -61.0, c = 0.1 in ethanol |
| Application | Efficient ligand for asymmetric hydrogenation of dehydroamino acids, methyl esters and ketones.1,2 |
| Melting point | 234-238 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
Precautionary statements
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(–)-4,12-Bis[di(3,5-xylyl)phosphino]-[2.2]-paracyclophane used for?
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(R)-(–)-4,12-Bis[di(3,5-xylyl)phosphino]-[2.2]-paracyclophane is an efficient chiral ligand used in asymmetric hydrogenation reactions for substrates such as dehydroamino acids, methyl esters, and ketones.
What is the CAS number and chemical formula for this compound?
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The CAS number is 325168-89-6, and the empirical formula is C48H50P2. The molecular weight is 688.86 g/mol.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product at a minimum assay of 97%. This compound is intended for research and chemical synthesis and is not supplied as USP, BP, or EP grade.
How should this chemical be handled and stored?
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This compound is classified as an irritant (H315, H319). Handle with appropriate personal protective equipment, including a dust mask (N95 US type), eyeshields, and gloves. Store in a well-ventilated place. Keep container tightly closed. In case of contact with eyes, rinse cautiously with water for several minutes, removing contact lenses if present and easy to do. Continue rinsing.
Can I request a sample or a quote?
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Yes, you can request a sample or a quote for (R)-(–)-4,12-Bis[di(3,5-xylyl)phosphino]-[2.2]-paracyclophane by contacting our sales team through the website or via email.
Is this product available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including this compound. Please contact us for export inquiries and associated logistics.
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