(R)-(+)-2-Pyrrolidone-5-carboxylic acid
(R)-(+)-2-Pyrrolidone-5-carboxylic acid (CAS 4042-36-8, C5H7NO3) is a chiral organic compound with a molecular weight of 129.11 g/mol. This derivative of glutamic acid finds application as a building block in chemical synthesis and research, particularly within peptide chemistry and the development of unnatural amino acids. Its specific stereochemistry makes it valuable for stereoselective reactions and in biochemical studies.
- IUPAC
- D-5-Oxo-2-pyrrolidinecarboxylic acid,D-Pyroglutamic acid

Chemical Synthesis
Serves as a chiral intermediate or building block in the synthesis of complex organic molecules and pharmaceuticals, leveraging its defined stereochemistry.
Peptide Chemistry
Used in the construction of modified peptides and peptidomimetics, contributing to the study of protein structure and function or the development of peptide-based therapeutics.
Biochemical Research
A tool for investigating biological pathways and enzyme mechanisms, often employed in research related to amino acid metabolism and neurotransmitter systems.
Unnatural Amino Acid Derivatives
Incorporated into novel amino acid structures to explore their properties and potential applications in medicinal chemistry and materials science.
| Molecular weight | 129.11 |
|---|---|
| Empirical formula | C5H7NO3 |
| Assay | 95% |
| Optical activity | [α]22/D +10°, c = 1.5 in H2O |
| Melting point | 155-156 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(+)-2-Pyrrolidone-5-carboxylic acid used for?
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(R)-(+)-2-Pyrrolidone-5-carboxylic acid is primarily used in chemical synthesis, peptide chemistry, biochemical research, and as a derivative for unnatural amino acids.
What is the CAS number and chemical formula for (R)-(+)-2-Pyrrolidone-5-carboxylic acid?
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The CAS number is 4042-36-8 and the chemical formula is C5H7NO3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of 95%. We do not represent it as USP, BP, EP, or pharmacopoeia grade.
How should (R)-(+)-2-Pyrrolidone-5-carboxylic acid be handled?
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Handle with appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves. Avoid breathing dust and ensure adequate ventilation as it may cause skin, eye, and respiratory irritation (H315, H319, H335).
Is (R)-(+)-2-Pyrrolidone-5-carboxylic acid available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including (R)-(+)-2-Pyrrolidone-5-carboxylic acid.
How can I request a sample or quote?
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To request a sample or a quote, please contact our sales team through the website or by phone, providing your specific requirements and shipping details.
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