(R)-(+)-3,3,3-Trifluoro-1,2-epoxypropane
(R)-(+)-3,3,3-Trifluoro-1,2-epoxypropane (CAS: 143142-90-9), a chiral epoxide with the molecular formula C3H3F3O and a molecular weight of 112.05, serves as a valuable building block in asymmetric synthesis. Its primary application involves the preparation of chiral aminopropanols from diarylamines, which have demonstrated potent inhibitory activity against Cholesteryl Ester Transfer Protein. This compound is offered by Tech Serve Solutions for advanced chemical research and development.
- IUPAC
- (R)-(+)-2-(Trifluoromethyl)oxirane
- Synonyms
- 2-epoxypropane(R)-(+)-2-(Trifluoromethyl)oxirane
Chiral Building Block for Aminopropanol Synthesis
This epoxide is utilized as a key substrate in the synthesis of chiral trifluoro aminopropanols. These derivatives are subsequently employed in studies targeting specific biological pathways, such as the inhibition of Cholesteryl Ester Transfer Protein.
Asymmetric Synthesis Applications
As a chiral epoxide, it is instrumental in introducing stereochemistry into target molecules. Its specific reactivity allows for controlled transformations, making it a crucial component in multi-step organic syntheses requiring enantiopurity.
Precursor for Pharmaceutical Intermediates
The unique trifluoromethyl group and chiral center make it a useful precursor for developing novel pharmaceutical intermediates. Its incorporation can influence the pharmacokinetic and pharmacodynamic properties of potential drug candidates.
| Molecular weight | 112.05 |
|---|---|
| Empirical formula | C3H3F3O |
| Assay | 97% |
| Boiling point | 25-32 °C |
| Density | 1.294 g/mL at 25 °C |
| Refractive index | n20/D <1.300 |
| Storage temperature | 2-8°C |
| Application | Substrate used to prepare chiral aminopropanols from diarylamines. The trifluoro amino propanols were found to be potent inhibitors of Cholesteryl Ester Transfer Protein.1 |
Hazard statements
- H224Extremely flammable liquid and vapour
- H319Causes serious eye irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US) |
|---|---|
| Flash point | -26 °C / -14.8 °F |
| Transport (UN / ADR) | UN 1993A 3 / PGI |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F+ |
| Risk statements (R) | 12 |
| Safety statements (S) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(+)-3,3,3-Trifluoro-1,2-epoxypropane used for?
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(R)-(+)-3,3,3-Trifluoro-1,2-epoxypropane is used as a substrate in the preparation of chiral aminopropanols from diarylamines, with these products serving as potent inhibitors of Cholesteryl Ester Transfer Protein. It is also employed as a chiral building block in asymmetric synthesis and for creating pharmaceutical intermediates.
What is the CAS number and molecular formula for this compound?
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The CAS number is 143142-90-9, and the molecular formula is C3H3F3O. The empirical formula in Hill notation is C3H3F3O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (R)-(+)-3,3,3-Trifluoro-1,2-epoxypropane with an assay of 97%. This product is suitable for research and chemical synthesis purposes and is not supplied as USP, BP, EP, or any other pharmacopoeial grade.
How should (R)-(+)-3,3,3-Trifluoro-1,2-epoxypropane be handled safely?
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This compound is highly flammable (H224) and causes serious eye irritation (H319). Handle with extreme care in a well-ventilated area, away from ignition sources. Appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, is essential. Refer to the Safety Data Sheet for detailed handling procedures.
How is this chemical packed and shipped?
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Tech Serve Solutions packs and ships (R)-(+)-3,3,3-Trifluoro-1,2-epoxypropane according to international transport regulations (UN 1993A 3 / PGI). Storage at 2-8°C is recommended to maintain product integrity. We export globally to meet your research and manufacturing needs.
How can I request a quote or sample?
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To request a quote or a sample of (R)-(+)-3,3,3-Trifluoro-1,2-epoxypropane, please visit the product page on our website and use the designated 'Request a Quote' or 'Sample Request' form, or contact our sales team directly.
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