(R)-(+)-2-[2-(Diphenylphosphino)phenyl]-4-isopropyl-2-oxazoline
(R)-(+)-2-[2-(Diphenylphosphino)phenyl]-4-isopropyl-2-oxazoline (CAS: 164858-78-0), a chiral phosphine-oxazoline ligand with the molecular formula C24H24NOP and a molecular weight of 373.43 g/mol. This compound is primarily utilised in asymmetric synthesis as a key component in catalytic systems. Its specific stereochemistry enables high enantioselectivity in various organic transformations, making it valuable for the synthesis of chiral molecules.
- IUPAC
- (R)-(+)-2-[2-(Diphenylphosphino)phenyl]-4,5-dihydro-4-isopropyl-oxazole
- Synonyms
- (R)-(+)-2-[2-(Diphenylphosphino)phenyl]-4,5-dihydro-4-isopropyl-oxazole
![(R)-(+)-2-[2-(Diphenylphosphino)phenyl]-4-isopropyl-2-oxazoline (C24H24NOP) — chemical structure, CAS 164858-78-0; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F164858-78-0.png&w=3840&q=75)
Asymmetric Catalysis
This ligand is extensively employed in transition-metal-catalyzed asymmetric reactions, such as hydrogenation, allylic alkylation, and cyclopropanation. It facilitates the formation of chiral products with high enantiomeric excess.
Chiral Ligand Development
As a privileged PHOX ligand, it serves as a valuable building block for developing new catalytic systems and exploring novel asymmetric transformations in organic synthesis.
Pharmaceutical Intermediate Synthesis
Its ability to control stereochemistry makes it instrumental in the synthesis of chiral pharmaceutical intermediates, where precise molecular configuration is critical for drug efficacy and safety.
| Molecular weight | 373.43 |
|---|---|
| Empirical formula | C24H24NOP |
| Assay | ≥97.0% (CHN) |
| Optical activity | [α]20/D +48±3°, c = 1.4% in chloroform |
| Melting point | 85-90 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(+)-2-[2-(Diphenylphosphino)phenyl]-4-isopropyl-2-oxazoline used for?
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This compound is primarily used as a chiral ligand in asymmetric catalysis to facilitate enantioselective synthesis of chiral molecules.
What are the CAS number and formula for this chemical?
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The CAS number is 164858-78-0 and the empirical formula is C24H24NOP.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with an assay of ≥97.0% (CHN). We do not represent this product as USP, BP, EP, or other pharmacopoeial grades.
How should (R)-(+)-2-[2-(Diphenylphosphino)phenyl]-4-isopropyl-2-oxazoline be handled?
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Handle with appropriate personal protective equipment including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. Avoid contact with eyes and skin. Refer to the Safety Data Sheet for detailed handling instructions.
Is this chemical a controlled substance?
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This chemical is not listed as a controlled substance in the provided data.
How is this product packed and shipped?
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This product is available for purchase and export globally by Tech Serve Solutions. Specific packaging details depend on order quantity and destination requirements.
How can I request a sample or quote?
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Please contact our sales team via the website or direct email to request a sample or a quotation for (R)-(+)-2-[2-(Diphenylphosphino)phenyl]-4-isopropyl-2-oxazoline.
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