(R)-(+)-2-Methyl-2-propanesulfinamide
(R)-(+)-2-Methyl-2-propanesulfinamide (CAS 196929-78-9) is a chiral auxiliary supplied by Tech Serve Solutions. With a molecular weight of 121.20 g/mol, this sulfur-based compound is instrumental in asymmetric synthesis. Its primary application involves its transformation into P,N-sulfinyl imine ligands, which are key intermediates in iridium-catalyzed asymmetric hydrogenation reactions, enabling the stereoselective synthesis of complex molecules.
Asymmetric Synthesis
This chiral auxiliary is crucial for asymmetric synthesis, facilitating stereoselective transformations. It is particularly useful in the preparation of chiral amines through the asymmetric hydrogenation of olefins.
Chiral Amine Synthesis
It serves as a precursor to P,N-sulfinyl imine ligands. These ligands are subsequently employed in iridium-catalyzed asymmetric hydrogenation, a vital process for constructing chiral amines with high enantiopurity.
Ligand Preparation
Condensation with aldehydes and ketones yields P,N-sulfinyl imine ligands. These intermediates are essential for advanced catalytic processes requiring stereochemical control.
| Molecular weight | 121.20 |
|---|---|
| Linear formula | (CH3)3CS(O)NH2 |
| Assay | 98% |
| Density | 0.903 g/mL at 25 °C0.903 g/mL at 25 °C |
| Refractive index | n20/D 1.420 |
| Concentration | 1 M in THF |
| Optical activity | [α]20/D +4°, c = 1.0242 in chloroform stab. with amylenes |
| Melting point | 103-107 °C(lit.) |
| Storage temperature | 2-8°C |
| Contains / stabiliser | BHT as inhibitor |
| Application | Can be readily transformed into P,N-sulfinyl imine ligands through condensation with aldehydes and ketones, which can undergo iridium-catalyzed asymmetric hydrogenation of olefins.1 |
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(+)-2-Methyl-2-propanesulfinamide used for?
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(R)-(+)-2-Methyl-2-propanesulfinamide is used in asymmetric synthesis as a chiral auxiliary. It can be readily transformed into P,N-sulfinyl imine ligands, which are utilized in iridium-catalyzed asymmetric hydrogenation of olefins.
What is the CAS number and formula for this chemical?
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The CAS number is 196929-78-9 and the linear formula is (CH3)3CS(O)NH2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (R)-(+)-2-Methyl-2-propanesulfinamide with an assay of 98%. This product is not represented as USP, BP, EP, or pharmacopoeia grade.
What are the safety and handling precautions for (R)-(+)-2-Methyl-2-propanesulfinamide?
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When handling, wear appropriate personal protective equipment including eyeshields, gloves, and a P1 (EN143) or N95 (US) respirator filter. It is classified under WGK Germany 3. Store at 2-8°C. Precautionary statements include P210, P261, P281, and P305 + P351 + P338.
How is this chemical shipped or exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. Specific shipping and export details for (R)-(+)-2-Methyl-2-propanesulfinamide can be provided upon inquiry.
How can I request a sample or a quote?
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To request a sample or a quote for (R)-(+)-2-Methyl-2-propanesulfinamide, please contact our sales department through the website or designated contact channels.
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