PD 98,059
PD 98,059 (CAS: 167869-21-8), with the molecular formula C16H13NO3 and a molecular weight of 267.28 g/mol, is a yellow solid. This compound is recognised as a selective inhibitor of MEK1, a key enzyme in the MAP kinase signaling pathway. It finds primary utility in biochemical research for studying cell signalling, gene expression, and cellular proliferation.
- IUPAC
- 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one,PD98059
- Synonyms
- 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-onePD98059
MEK1 Inhibition Studies
PD 98,059 selectively inhibits Mitogen-activated protein kinase kinase 1 (MEK1), playing a crucial role in the MAPK/ERK signaling pathway. It is extensively used to investigate the downstream effects of MEK inhibition on cell growth and differentiation.
Cellular Signaling Research
As a tool in cell biology, PD 98,059 helps researchers elucidate complex cellular signaling cascades. Its application aids in understanding pathways involved in cellular responses to various stimuli and in maintaining cellular homeostasis.
Neuroscience Investigations
This compound is valuable in neuroscience research for studying the roles of MAPK pathways in neuronal function and plasticity. It can be employed to examine the impact of MEK inhibition on neural processes.
Molecular Biology Assays
PD 98,059 serves as a probe in molecular biology experiments focusing on gene expression regulation. Its use can help determine the dependency of specific gene activation on the MEK/ERK pathway.
| Molecular weight | 267.28 |
|---|---|
| Empirical formula | C16H13NO3 |
| Form | solid |
| Colour | yellow |
| Solubility | DMSO: soluble10 mg/mL, clear |
| Storage temperature | −20°C |
Hazard statements
- H301Toxic if swallowed
Precautionary statements
- P301IF SWALLOWED
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is PD 98,059 used for?
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PD 98,059 is primarily used in research to selectively inhibit MEK1, a key enzyme in the MAPK/ERK signaling pathway. It aids in the study of cellular signaling, gene expression, cell proliferation, and related processes in cell biology and neuroscience.
What are the CAS number and formula for PD 98,059?
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The CAS number for PD 98,059 is 167869-21-8, and its empirical formula is C16H13NO3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies PD 98,059 as a research-grade chemical. The specific purity and assay details are available on the product's Certificate of Analysis. We do not represent this product as USP, BP, or EP grade.
How should PD 98,059 be handled safely?
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PD 98,059 is classified as toxic if swallowed (H301) and requires careful handling. Use appropriate personal protective equipment, including a dust mask (N95), eyeshields, face shields, and gloves. Handle only in a well-ventilated area. Refer to the Safety Data Sheet for comprehensive safety information.
Is PD 98,059 a controlled substance?
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Based on the provided data, PD 98,059 is not indicated as a controlled substance.
How is PD 98,059 packaged and shipped?
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PD 98,059 is typically supplied as a solid and is packaged according to industry standards for chemical reagents. It is shipped globally by Tech Serve Solutions in compliance with relevant transportation regulations.
How can I request a sample or quote for PD 98,059?
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To request a sample or obtain a quote for PD 98,059, please contact our sales department via the website or by phone, providing your contact details and the quantity required.
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