2-Chloro-3,5-difluoroanisole
2-Chloro-3,5-difluoroanisole (CAS 18627-23-1) is a halogenated aromatic ether, identified by its linear formula ClC<sub>6</sub>H<sub>2</sub>(F)<sub>2</sub>OCH<sub>3</sub> and a molecular weight of 178.56 g/mol. This organic building block is primarily utilised in chemical synthesis and as an intermediate in the development of more complex molecules. Its specific substitution pattern makes it a valuable reagent for introducing difluoroanisole moieties into organic structures, finding application in research and development laboratories.
- Synonyms
- ClC6H2(F)2OCH3

Organic Synthesis Intermediate
Serves as a key building block in the multi-step synthesis of complex organic compounds. Its distinct halogen and ether functionalities allow for targeted chemical transformations.
Research and Development
Employed in academic and industrial R&D settings for exploring new synthetic routes and developing novel chemical entities. It is particularly useful for incorporating fluorinated aromatic rings.
Fine Chemical Production
Utilised in the preparation of fine chemicals, where precise structural control is paramount. The compound's reactive sites are amenable to various coupling and substitution reactions.
| Molecular weight | 178.56 |
|---|---|
| Linear formula | ClC6H2(F)2OCH3 |
| Assay | 98% |
| Melting point | 55-58 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloro-3,5-difluoroanisole used for?
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2-Chloro-3,5-difluoroanisole (CAS 18627-23-1) is used as an organic building block in chemical synthesis and research and development.
What is the CAS number and formula for 2-Chloro-3,5-difluoroanisole?
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The CAS number is 18627-23-1 and the linear formula is ClC<sub>6</sub>H<sub>2</sub>(F)<sub>2</sub>OCH<sub>3</sub>.
What grade and purity does Tech Serve Solutions supply for 2-Chloro-3,5-difluoroanisole?
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Tech Serve Solutions supplies 2-Chloro-3,5-difluoroanisole with a minimum assay of 98%. This product is not intended for USP, BP, EP, pharmaceutical, nutraceutical, or food applications.
How should 2-Chloro-3,5-difluoroanisole be handled safely?
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2-Chloro-3,5-difluoroanisole is classified as a Warning with hazards H315 (causes skin irritation), H319 (causes serious eye irritation), and H335 (may cause respiratory irritation). Handle with appropriate personal protective equipment including eyeshields, gloves, and a dust mask type N95 (US). Ensure adequate ventilation and avoid breathing dust.
Is 2-Chloro-3,5-difluoroanisole a controlled substance?
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This chemical is not listed as a controlled substance based on the provided data.
How is 2-Chloro-3,5-difluoroanisole packed, shipped, and exported?
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Tech Serve Solutions, a global supplier since 1998, meticulously packs, ships, and exports fine chemicals adhering to all relevant international regulations for safe and compliant transit.
How can I request a quote or sample of 2-Chloro-3,5-difluoroanisole?
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To request a quote or sample, please contact our sales department through the website or by phone, referencing product CAS 18627-23-1.
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