2-Chloro-2′,4′-difluoroacetophenone
2-Chloro-2′,4′-difluoroacetophenone (CAS 51336-94-8) is a fluorinated organic compound with the linear formula F<sub>2</sub>C<sub>6</sub>H<sub>3</sub>COCH<sub>2</sub>Cl and a molecular weight of 190.57 g/mol. This ketone serves as a valuable building block in organic synthesis, particularly in the creation of more complex fluorinated molecules. Its reactive nature makes it suitable for various chemical transformations in research and development settings.
- Synonyms
- F2C6H3COCH2Cl
Synthesis of Allyl Alcohol Derivatives
2-Chloro-2′,4′-difluoroacetophenone has been documented for use in the synthesis of allyl alcohol, acting as a key intermediate in the reaction pathway. This application highlights its utility in constructing specific organic frameworks.
Fluorinated Building Block
As a member of the Aryl Fluorinated Building Blocks category, this compound is employed in organic synthesis to introduce difluorophenyl ketone moieties into target molecules. Its structure facilitates further functionalization in chemical research.
Ketone Chemistry
The presence of the acetophenone core with a chlorine substituent makes 2-Chloro-2′,4′-difluoroacetophenone a useful reagent in reactions involving ketones and alpha-haloketones. It can participate in various nucleophilic substitution and condensation reactions.
| Molecular weight | 190.57 |
|---|---|
| Linear formula | F2C6H3COCH2Cl |
| Assay | 98% |
| Application | 2-Chloro-2′,4′-difluoroacetophenone was used in the synthesis of allyl alcohol1. |
| Melting point | 44-48 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34-37 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... PTPN6(5777) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloro-2′,4′-difluoroacetophenone used for?
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2-Chloro-2′,4′-difluoroacetophenone is used as a building block in organic synthesis, particularly noted for its role in the preparation of allyl alcohol derivatives and for introducing fluorinated phenyl ketone structures into target molecules.
What is the CAS number and formula for 2-Chloro-2′,4′-difluoroacetophenone?
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The CAS number is 51336-94-8, and the linear formula is F<sub>2</sub>C<sub>6</sub>H<sub>3</sub>COCH<sub>2</sub>Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Chloro-2′,4′-difluoroacetophenone with an assay of 98%. This compound is supplied for research and laboratory use; TSS does not represent it as USP, BP, EP, or pharmaceutical grade.
How should 2-Chloro-2′,4′-difluoroacetophenone be handled safely?
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This compound is classified as Danger (GHS05) and causes severe skin burns and eye damage (H314). Handle with appropriate personal protective equipment including eyeshields, face shields, chemical-resistant gloves, and respiratory protection. Ensure adequate ventilation.
Is 2-Chloro-2′,4′-difluoroacetophenone shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 2-Chloro-2′,4′-difluoroacetophenone, and handles international shipments.
How can I request a quote or sample for 2-Chloro-2′,4′-difluoroacetophenone?
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To request a quote or a sample of 2-Chloro-2′,4′-difluoroacetophenone, please contact the Tech Serve Solutions sales team via the website or by phone, providing your specific requirements.
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