O-(2,3,4,5,6-Pentafluorobenzyl)hydroxylamine hydrochloride
O-(2,3,4,5,6-Pentafluorobenzyl)hydroxylamine hydrochloride (CAS 57981-02-9) is a fluorinated organic building block with the molecular formula C₆F₅CH₂ONH₂·HCl and a molar mass of 249.57 g/mol. This compound serves as a versatile derivatization reagent for the detection and analysis of carbonyl-containing compounds, including aldehydes, ketones, and acids, via methods such as GC and GC-MS. It is also utilised in the synthesis of other complex organic molecules.
- IUPAC
- PFBHA·HCl
- Synonyms
- 5,6-Pentafluorobenzyl)hydroxylamine hydrochlorideC6F5CH2ONH2·HClPFBHA·HCl
Derivatization Reagent for Carbonyl Compounds
This compound is employed as a derivatization reagent for the sensitive determination of various carbonyl-containing analytes, including aldehydes, ketones, and carboxylic acids. Its application is particularly valuable in chromatographic techniques like Gas Chromatography (GC) and Gas Chromatography-Mass Spectrometry (GC-MS) for enhanced detection.
Synthesis of Steroid Oximes
O-(2,3,4,5,6-Pentafluorobenzyl)hydroxylamine hydrochloride has been documented for use in the preparation of oximes derived from steroids possessing a keto functional group. This application highlights its utility in modifying complex organic structures for further chemical study or synthesis.
Analytical Chemistry Applications
The reagent is instrumental in analytical procedures for quantifying biologically significant molecules such as thromboxane B₂, prostaglandins, and amygdalin. Its ability to react with carbonyls makes it a key tool for chemists in various analytical fields.
| Molecular weight | 249.57 |
|---|---|
| Linear formula | C6F5CH2ONH2·HCl |
| Assay | ≥98% |
| Solubility | water: soluble50 mg/mL, clear to slightly hazy, colorless |
| Application | • O-(2,3,4,5,6-Pentafluorobenzyl)hydroxylamine hydrochloride was used in the preparation of oximes of steroids bearing keto group1.• It was used as derivatization reagent in the determination of thromboxane B2, prostaglandins, amygdalin and a variety of aldehydes, ketones and acids2.• It is a versatile reagent used for the detection of carbonyl-containing compounds by GC, GC-MS and other methods2. |
| Melting point | 227 °C (subl.)(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is O-(2,3,4,5,6-Pentafluorobenzyl)hydroxylamine hydrochloride primarily used for?
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O-(2,3,4,5,6-Pentafluorobenzyl)hydroxylamine hydrochloride is primarily used as a derivatization reagent for the detection and analysis of carbonyl-containing compounds, such as aldehydes, ketones, and acids, particularly by GC and GC-MS.
What are the CAS number and molecular formula for this compound?
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The CAS number is 57981-02-9, and the molecular formula is C₆F₅CH₂ONH₂·HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies O-(2,3,4,5,6-Pentafluorobenzyl)hydroxylamine hydrochloride with an assay of ≥98%. TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling precautions for this chemical?
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Handle with care, using appropriate personal protective equipment including eyeshields and gloves. Ensure adequate ventilation and use a P1 (EN143) or N95 (US) respirator filter if needed. The compound is classified under WGK Germany 3, indicating it is hazardous to water.
How is this chemical shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and laboratory reagents, capable of shipping and exporting O-(2,3,4,5,6-Pentafluorobenzyl)hydroxylamine hydrochloride worldwide.
How can I request a sample or quote for O-(2,3,4,5,6-Pentafluorobenzyl)hydroxylamine hydrochloride?
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To request a sample or a quote, please contact our sales team through the dedicated contact channels on the Tech Serve Solutions website.
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