O,O′-Diethyl chlorothiophosphate
O,O′-Diethyl chlorothiophosphate (CAS: 2524-04-1) is a phosphorus compound with a molecular weight of 188.61 g/mol. This chemical serves as a valuable phosphorylating agent and organic building block in synthetic chemistry. Its reactivity makes it suitable for diverse chemical synthesis processes, particularly in the development of complex organic molecules. Tech Serve Solutions supplies this reagent for laboratory and industrial applications, adhering to strict quality standards.
- IUPAC
- O,O′-Diethylthiophosphoric chloride,Diethyl phosphorochloridothionate
- Synonyms
- (CH3CH2O)2P=(S)ClO,O′-Diethylthiophosphoric chlorideDiethyl phosphorochloridothionate

Phosphorylating Agent
O,O′-Diethyl chlorothiophosphate is employed as a phosphorylating agent in organic synthesis. It facilitates the introduction of thiophosphoryl groups into various substrates, enabling the construction of diverse organophosphorus compounds.
Organic Synthesis Building Block
As a versatile organic building block, this compound is utilized in the synthesis of complex molecules. Its functional groups allow for a range of chemical transformations, supporting research and development in pharmaceuticals and agrochemicals.
Chemical Synthesis Reagent
This chemical finds application as a reagent in various chemical synthesis pathways. It is integral to the production of fine chemicals and intermediates where precise control over phosphorus chemistry is required.
| Molecular weight | 188.61 |
|---|---|
| Linear formula | (CH3CH2O)2P=(S)Cl |
| Assay | 97% |
| Boiling point | 45 °C/3 mmHg(lit.) |
| Density | 1.2 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.472(lit.) |
| Vapour pressure | 1.4 mmHg (50 °C) |


Hazard statements
- H301Toxic if swallowed
- H311Toxic in contact with skin
- H314Causes severe skin burns and eye damage
- H331Toxic if inhaled
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 2751 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 23/24/25-34 |
| Safety statements (S) | 23-26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is O,O′-Diethyl chlorothiophosphate used for?
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O,O′-Diethyl chlorothiophosphate is primarily used as a phosphorylating agent and an organic building block in chemical synthesis. It is valuable for introducing thiophosphoryl groups and constructing complex organophosphorus compounds.
What is the CAS number and formula for O,O′-Diethyl chlorothiophosphate?
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The CAS number for O,O′-Diethyl chlorothiophosphate is 2524-04-1. The linear formula is (CH3CH2O)2P=(S)Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies O,O′-Diethyl chlorothiophosphate with a purity of 97%. We do not represent this product as USP, BP, or EP grade.
How should O,O′-Diethyl chlorothiophosphate be handled safely?
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This compound is hazardous and requires careful handling. It is classified as Danger, with hazards including H301, H311, H314, and H331. Always use appropriate personal protective equipment, including gloves, goggles, and a suitable respirator, and follow safety protocols.
How is O,O′-Diethyl chlorothiophosphate shipped and exported?
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O,O′-Diethyl chlorothiophosphate is shipped and exported under UN 2751, Hazard Class 8, Packing Group II, as per ADR regulations.
How can I request a sample or quote for O,O′-Diethyl chlorothiophosphate?
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To request a sample or a quotation for O,O′-Diethyl chlorothiophosphate, please contact our sales team through the website or via direct inquiry.
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