O,O′-Bis[2-(N-Succinimidyl-succinylamino)ethyl]polyethylene glycol
O,O′-Bis[2-(N-Succinimidyl-succinylamino)ethyl]polyethylene glycol (CAS 186020-53-1) is a homobifunctional polyethylene glycol derivative. It features two N-Hydroxysuccinimide (NHS) ester termini, making it highly reactive towards primary amines. This linker is invaluable for bioconjugation, protein modification, and the preparation of advanced materials, enabling controlled attachment of molecules or surfaces.
- IUPAC
- α,ω-Bis-NHS-PEG,Di(N-succinimidyl) PEG-diacid,PEG-bis(N-succinimidyl succinate)
- Synonyms
- α,ω-Bis-NHS-PEGDi(N-succinimidyl) PEG-diacidPEG-bis(N-succinimidyl succinate)
![O,O′-Bis[2-(N-Succinimidyl-succinylamino)ethyl]polyethylene glycol — chemical structure, CAS 186020-53-1; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F186020-53-1.png&w=3840&q=75)
Bioconjugation
The dual NHS ester groups readily react with amine groups on proteins, antibodies, or peptides, facilitating the formation of stable amide bonds for creating antibody-drug conjugates (ADCs), labelled biomolecules, or modified surfaces.
Surface Modification
Immobilise biomolecules or other active agents onto surfaces functionalised with primary amines. This application is crucial in developing biosensors, diagnostic assays, and biocompatible implant coatings.
Hydrogel Formation
Crosslink polymer chains containing amine groups to form hydrogels for drug delivery systems or tissue engineering scaffolds. The PEG backbone provides favourable biocompatibility and tunable properties.
PEGylation of Biomolecules
Enhance the solubility, stability, and pharmacokinetic profile of therapeutic proteins or peptides by conjugating this PEG derivative. The succinimidyl ester ensures efficient and site-specific modification.
| Storage temperature | −20°C |
|---|
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is O,O′-Bis[2-(N-Succinimidyl-succinylamino)ethyl]polyethylene glycol used for?
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This compound is primarily used for bioconjugation and surface modification due to its homobifunctional nature with two reactive NHS ester termini, suitable for crosslinking and labelling applications.
What are the CAS number and formula for O,O′-Bis[2-(N-Succinimidyl-succinylamino)ethyl]polyethylene glycol?
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The CAS number is 186020-53-1. The chemical formula is not provided in the product data.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product for research and laboratory use. Purity details are not specified in the provided data, and it is not represented as USP, BP, or EP grade.
How should O,O′-Bis[2-(N-Succinimidyl-succinylamino)ethyl]polyethylene glycol be handled safely?
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Handle with appropriate personal protective equipment, including eyeshields, gloves, and a type N95 or P1 respirator, as indicated by the safety data. Store at −20°C.
Is O,O′-Bis[2-(N-Succinimidyl-succinylamino)ethyl]polyethylene glycol a controlled substance?
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The provided data does not indicate that this compound is a controlled substance.
How is O,O′-Bis[2-(N-Succinimidyl-succinylamino)ethyl]polyethylene glycol packed, shipped, or exported?
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Detailed packing and shipping information is not available in the provided data. As a global supplier, Tech Serve Solutions handles international export procedures for its chemical products.
How can I request a sample or quote for O,O′-Bis[2-(N-Succinimidyl-succinylamino)ethyl]polyethylene glycol?
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Please contact the Tech Serve Solutions sales team via the website or listed contact details to request a sample or a quotation for this product.
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