(R)-Ethyl piperidine-3-carboxylate
(R)-Ethyl piperidine-3-carboxylate (CAS: 25137-01-3, C8H15NO2) is a chiral building block with a molecular weight of 157.21 g/mol. This heterocyclic compound serves as a key reactant in the synthesis of various pharmaceutical agents. Its specific stereochemistry makes it valuable in asymmetric synthesis, contributing to the development of complex molecules for therapeutic applications. Tech Serve Solutions offers this compound for research and chemical synthesis purposes.
- IUPAC
- (R)-ethyl nipecotate,(R)-Piperidine-3-carboxylic acid ethyl ester
- Synonyms
- (R)-ethyl nipecotate(R)-Piperidine-3-carboxylic acid ethyl ester
Synthesis of Pharmaceutical Intermediates
This compound is a crucial reactant in the preparation of DPP-4 inhibitors and dual H1/5-HT2A receptor antagonists used in treating sleep disorders. It is also employed in the synthesis of serotonin and noradrenaline reuptake inhibitors, as well as GABA uptake inhibitors, highlighting its versatility in drug discovery.
Stereocontrolled Chemical Reactions
It serves as a reactant for stereocontrolled hydroiodination of alkynes, a valuable transformation in organic synthesis for creating chiral centers with high selectivity. This application underscores its utility in advanced synthetic methodologies.
Development of Anti-Anxiety Agents
The compound has been utilised in the development pathway for an orally potent anti-anxiety drug. Its chiral nature is integral to the pharmacological activity of the final therapeutic agent.
| Molecular weight | 157.21 |
|---|---|
| Empirical formula | C8H15NO2 |
| Assay | 97% |
| Density | 1.092 g/mL at 25 °C |
| Application | Reactant for synthesis of:• DPP-4 inhibitors1• Dual H1/5-HT2A receptor antagonists for treatment of sleep disorders2• Serotonin and noradrenaline reuptake inhibitors3• GABA uptake inhibitors4Reactant for stereocontrolled hydoiodination of alkynes5Used for an orally potent anti-anxiety drug6 |
Hazard statements
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 104 °C / 219.2 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 37/38-41 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-Ethyl piperidine-3-carboxylate used for?
+
(R)-Ethyl piperidine-3-carboxylate is used as a reactant in the synthesis of pharmaceutical agents such as DPP-4 inhibitors, dual H1/5-HT2A receptor antagonists, serotonin and noradrenaline reuptake inhibitors, and GABA uptake inhibitors. It is also used in stereocontrolled hydroiodination of alkynes and in the development of anti-anxiety drugs.
What are the CAS number and formula for (R)-Ethyl piperidine-3-carboxylate?
+
The CAS number is 25137-01-3, and the empirical formula is C8H15NO2.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies (R)-Ethyl piperidine-3-carboxylate with an assay of 97%. This is a technical/research grade material, and TSS does not represent it as USP, BP, EP, or other pharmacopoeia grades.
What are the safety considerations when handling this chemical?
+
This compound is classified as Danger, with hazards including skin irritation (H315), serious eye damage (H318), and respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields and gloves, is essential. Use in a well-ventilated area or with respiratory protection is recommended.
How is (R)-Ethyl piperidine-3-carboxylate packed, shipped, and exported?
+
Tech Serve Solutions packs, ships, and exports chemicals according to international safety and regulatory standards, ensuring secure transit for research and industrial applications worldwide.
How can I request a sample or quote for (R)-Ethyl piperidine-3-carboxylate?
+
To request a sample or obtain a quote, please visit the Tech Serve Solutions website or contact our sales team directly with your specific requirements.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis