Nicorandil
Nicorandil (CAS: 65141-46-0), with the molecular formula C8H9N3O4 and a molecular weight of 211.17 g/mol, is a white to off-white powder. This compound functions as a potassium channel opener and nitric oxide donor. It is primarily utilised in scientific research settings, particularly in studies focusing on cardiovascular physiology and cell signalling, owing to its ion channel modulating properties.
- IUPAC
- 2-(Pyridine-3-carbonylamino)ethyl nitrate,2-Nicotinamidoethyl nitrate,Ikorel,N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide,SG-75,Sigmart,Zynicor
- Synonyms
- 2-(Pyridine-3-carbonylamino)ethyl nitrate2-Nicotinamidoethyl nitrateIkorelN-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamideSG-75SigmartZynicor
Ion Channel Research
Nicorandil serves as a valuable tool for investigating the function and regulation of various ion channels, particularly potassium channels. Its mechanism of action as a potassium channel opener makes it useful in electrophysiology and pharmacology studies.
Cardiovascular Studies
Due to its vasodilatory properties and effects on cardiac ion channels, Nicorandil is employed in research related to cardiovascular diseases. It aids in understanding mechanisms of ischaemia-reperfusion injury and cardiac electrophysiology.
Cell Signalling Investigations
As a modulator of cellular signalling pathways involving ion transport and nitric oxide, Nicorandil can be used in biochemical assays and cell-based studies. This helps in elucidating complex signalling cascades within biological systems.
| Molecular weight | 211.17 |
|---|---|
| Empirical formula | C8H9N3O4 |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white to off-white |
| Solubility | DMSO: >10 mg/mL |
| Storage temperature | room temp |
Hazard statements
- H302Harmful if swallowed
- H318Causes serious eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-41 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Nicorandil used for?
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Nicorandil is used in scientific research for investigating ion channels, cardiovascular physiology, and cell signalling, owing to its properties as a potassium channel opener and nitric oxide donor.
What is the CAS number and molecular formula for Nicorandil?
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The CAS number for Nicorandil is 65141-46-0, and its molecular formula is C8H9N3O4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Nicorandil with a purity of ≥98% by HPLC. This product is intended for research purposes and is not supplied as USP, BP, EP, or any other pharmacopoeial grade.
How should Nicorandil be handled safely?
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Nicorandil is classified as hazardous. It is harmful if swallowed (H302) and causes serious eye damage (H318). Handle with appropriate personal protective equipment, including a dust mask (N95 US type), eyeshields, and gloves. Avoid contact with eyes and skin, and do not ingest.
How is Nicorandil packed and shipped?
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Nicorandil is typically supplied as a white to off-white powder and stored at room temperature. Tech Serve Solutions is a global supplier and exporter, adhering to all regulations for international chemical shipments.
How can I request a sample or quote for Nicorandil?
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To request a sample or a quote for Nicorandil, please contact our sales team through the website or by phone, providing your specific requirements.
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