3-(Trifluoromethyl)piperidine
3-(Trifluoromethyl)piperidine (CAS 768-31-0), with the molecular formula C6H10F3N and a molecular weight of 153.15 g/mol, is a heterocyclic building block. This compound is synthesised for its utility in medicinal chemistry. It serves as a key reactant in the development of novel therapeutic agents, including positive allosteric modulators for metabotropic glutamate receptor subtype 4 and ligands for the 5-HT7 receptor.
Metabotropic Glutamate Receptor Modulators
Used as a reactant in the synthesis of positive allosteric modulators targeting the metabotropic glutamate receptor subtype 4. This application is significant in neurochemical research for potential therapeutic interventions.
5-HT7 Receptor Ligand Synthesis
Employed as a precursor in the development of selective ligands for the 5-HT7 receptor. Research in this area is crucial for understanding serotonergic pathways and developing treatments for neurological and psychiatric disorders.
Chemical Synthesis Intermediate
A versatile building block utilised in organic synthesis, particularly for the introduction of the trifluoromethylpiperidine moiety into complex molecules. Its structure lends itself to diverse synthetic strategies.
| Molecular weight | 153.15 |
|---|---|
| Empirical formula | C6H10F3N |
| Assay | 97% |
| Boiling point | 74-75 °C/33 mmHg |
| Density | 1.154 g/mL at 25 °C |
| Refractive index | n20/D 1.393 |
| Storage temperature | 2-8°C |
| Application | Reactant for synthesis of positive allosteric modulators of metabotropic glutamate receptor subtype 41Reactant for 5-HT7 receptor ligands2 |
Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 28 °C / 82.4 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-(Trifluoromethyl)piperidine used for?
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3-(Trifluoromethyl)piperidine (CAS 768-31-0) is used as a reactant for the synthesis of positive allosteric modulators of metabotropic glutamate receptor subtype 4 and for 5-HT7 receptor ligands. It functions as a valuable building block in chemical synthesis.
What are the CAS number and formula for 3-(Trifluoromethyl)piperidine?
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The CAS number for 3-(Trifluoromethyl)piperidine is 768-31-0, and its empirical formula (Hill notation) is C6H10F3N.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-(Trifluoromethyl)piperidine with a minimum assay of 97%. We do not represent this product as USP, BP, EP, or pharmaceutical grade unless explicitly stated in the product specifications.
How should 3-(Trifluoromethyl)piperidine be handled and stored?
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3-(Trifluoromethyl)piperidine is a flammable liquid and vapour (H226) and can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). It should be handled in a well-ventilated area, away from ignition sources, and stored at 2-8°C. Appropriate personal protective equipment, including eyeshields and gloves, is recommended.
How is 3-(Trifluoromethyl)piperidine shipped?
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3-(Trifluoromethyl)piperidine is shipped as a UN 1993C 3 / PGIII classified material, indicating it is a flammable liquid. TSS ensures compliance with all relevant shipping regulations for international export.
How can I request a sample or quote for 3-(Trifluoromethyl)piperidine?
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To request a sample or obtain a quote for 3-(Trifluoromethyl)piperidine, please contact our sales department through the website or by phone, referencing the product name and CAS number 768-31-0.
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