3-(Trifluoromethyl)phenylboronic acid
3-(Trifluoromethyl)phenylboronic acid (CAS: 1423-26-3), with the molecular formula CF3C6H4B(OH)2 and a molecular weight of 189.93 g/mol, is a valuable organoboron compound. It functions as a key building block in organic synthesis, particularly in palladium-catalyzed cross-coupling reactions and other sophisticated transformations. This compound is essential for the synthesis of complex molecules in pharmaceutical and materials science research.
- IUPAC
- 3-(Trifluoromethyl)benzeneboronic acid,a,a,a-Trifluoro-m-tolueneboronic acid
- Synonyms
- 3-(Trifluoromethyl)benzeneboronic acida,a,a-Trifluoro-m-tolueneboronic acid
Suzuki-Miyaura Cross-Coupling Reactions
This aryl boronic acid is a crucial reactant in Suzuki-Miyaura cross-coupling reactions, enabling the formation of carbon-carbon bonds. These reactions are fundamental in the synthesis of complex organic molecules.
Aerobic Oxidative Cross-Coupling
It participates in aerobic oxidative cross-coupling methodologies, offering an efficient route for constructing biaryl compounds under mild conditions.
Microwave-Assisted Petasis Reactions
The compound is employed in microwave-assisted Petasis reactions, facilitating the synthesis of substituted amines and related structures.
Rhodium-Catalyzed Addition Reactions
It serves as a substrate in rhodium-catalyzed addition reactions, contributing to the construction of intricate molecular frameworks.
Synthesis of Biologically Active Molecules
3-(Trifluoromethyl)phenylboronic acid is utilised in the synthesis of various biologically active molecules, highlighting its importance in medicinal chemistry research and drug discovery.
| Molecular weight | 189.93 |
|---|---|
| Linear formula | CF3C6H4B(OH)2 |
| Application | Reactant involved in:• Suzuki-Miyaura cross-coupling reactions1• Aerobic oxidative cross-coupling2• Microwave-assisted Petasis reactions3• Rhodium-catalyzed addition reactions4,5• Syntehsis of biologically active molecules6 |
| Melting point | 163-166 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-(Trifluoromethyl)phenylboronic acid used for?
+
This compound is primarily used as a reactant in various organic synthesis reactions, including Suzuki-Miyaura cross-coupling, aerobic oxidative cross-coupling, microwave-assisted Petasis reactions, and rhodium-catalyzed addition reactions. It is also important for the synthesis of biologically active molecules.
What is the CAS number and chemical formula for 3-(Trifluoromethyl)phenylboronic acid?
+
The CAS number is 1423-26-3, and the chemical formula is CF3C6H4B(OH)2.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 3-(Trifluoromethyl)phenylboronic acid as a research-grade chemical. The specific purity and assay are detailed in the product's Certificate of Analysis, and TSS does not represent this product as USP, BP, EP, or pharmaceutical grade.
What are the safety and handling considerations for 3-(Trifluoromethyl)phenylboronic acid?
+
Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used. The compound is classified under WGK 2 in Germany, indicating it is hazardous to water.
How is 3-(Trifluoromethyl)phenylboronic acid packed and shipped?
+
Tech Serve Solutions packs and exports chemicals adhering to international shipping regulations. Please contact us for specific details regarding packaging for your region.
How can I request a sample or quote for 3-(Trifluoromethyl)phenylboronic acid?
+
To request a sample or a quote, please contact the TSS sales team through our website or by calling our offices. Provide the product name and CAS number for prompt service.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis