3-(Trifluoromethyl)pyrazole
3-(Trifluoromethyl)pyrazole (CAS: 20154-03-4), with the molecular formula C4H3F3N2 and a molecular weight of 136.08 g/mol, is a heterocyclic building block. This compound is primarily utilised in chemical synthesis, particularly in copper-catalyzed pyrazole N-arylation reactions. Its defined structure and reactivity make it a valuable reagent for organic chemists developing novel compounds and materials.
Pyrazole N-Arylation
This compound serves as a key reactant in copper-catalyzed N-arylation of pyrazoles. This method is crucial for forming C-N bonds, a common motif in pharmaceuticals and organic materials.
Heterocyclic Synthesis
As a trifluoromethyl-substituted pyrazole, it acts as a versatile building block for constructing more complex heterocyclic molecules. The trifluoromethyl group can influence electronic properties and metabolic stability in target compounds.
Organic Synthesis Reagent
3-(Trifluoromethyl)pyrazole is employed in various organic transformations requiring a functionalised pyrazole core. Its inclusion in synthetic routes allows for the introduction of specific structural and electronic features.
| Molecular weight | 136.08 |
|---|---|
| Empirical formula | C4H3F3N2 |
| Assay | 99% |
| Boiling point | 70 °C/2 mmHg(lit.) |
| Application | Used in copper-catalyzed pyrazole N-arylation.1,2 |
| Melting point | 45-47 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-(Trifluoromethyl)pyrazole used for?
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3-(Trifluoromethyl)pyrazole is used in chemical synthesis, notably for copper-catalyzed pyrazole N-arylation reactions. It functions as a heterocyclic building block for creating more complex organic molecules.
What is the CAS number and formula for 3-(Trifluoromethyl)pyrazole?
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The CAS number for 3-(Trifluoromethyl)pyrazole is 20154-03-4, and its empirical formula (Hill Notation) is C4H3F3N2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-(Trifluoromethyl)pyrazole with an assay of 99%. We do not represent this product as USP, BP, or EP grade; it is supplied for research and laboratory use.
How should 3-(Trifluoromethyl)pyrazole be handled safely?
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3-(Trifluoromethyl)pyrazole is classified with GHS07 (Warning) and carries hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Recommended personal protective equipment includes a dust mask type N95 (US), eyeshields, and gloves. Ensure adequate ventilation.
Is 3-(Trifluoromethyl)pyrazole a controlled substance?
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The provided data does not indicate that 3-(Trifluoromethyl)pyrazole is a controlled substance.
How is 3-(Trifluoromethyl)pyrazole packaged and exported?
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As a specialist global supplier, Tech Serve Solutions expertly handles the packaging and export of fine chemicals like 3-(Trifluoromethyl)pyrazole, adhering to all relevant shipping regulations.
How can I request a quote or sample for 3-(Trifluoromethyl)pyrazole?
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To request a quote or sample for 3-(Trifluoromethyl)pyrazole, please use the contact form on our website or contact our sales department directly.
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