3-(Trifluoromethyl)phenylacetone
3-(Trifluoromethyl)phenylacetone (CAS: 21906-39-8) is a key organic building block with the molecular formula CF₃C₆H₄CH₂COCH₃ and a molecular weight of 202.17 g/mol. This ketone is primarily utilised in chemical synthesis. Its specific structure makes it a valuable intermediate for creating more complex molecules, particularly in the development of novel pharmaceutical compounds and research chemicals. Tech Serve Solutions provides this compound with an assay of 97%.
- IUPAC
- 1-(α,α,α-Trifluoro-m-tolyl)-2-propanone
- Synonyms
- 1-(alpha,alpha,alpha-Trifluoro-m-tolyl)-2-propanone
Synthesis of Amines via Reductive Amination
3-(Trifluoromethyl)phenylacetone can be employed in reductive amination reactions to produce substituted propylamine derivatives. For instance, it has been used in the synthesis of (±)-[1-(3-trifluoromethyl)phenyl]-2-propylamine.
Intermediate for Heterocyclic Compounds
The carbonyl functionality and the trifluoromethylphenyl group make this compound a versatile precursor for constructing various heterocyclic systems. These systems are often explored in medicinal chemistry for potential therapeutic applications.
Precursor for Functionalised Alcohols
Reduction of the ketone group or subsequent reactions can lead to the formation of functionalised alcohols. An example includes its role as a precursor in the synthesis of N-{2-[1-methyl-2-(3-trifluorome thylphenyl]}-aminoethanol.
| Molecular weight | 202.17 |
|---|---|
| Linear formula | CF3C6H4CH2COCH3 |
| Assay | 97% |
| Boiling point | 89-90 °C/0.5 mmHg(lit.) |
| Density | 1.204 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.457(lit.) |
| Application | 3-(Trifluoromethyl)phenylacetone was used in the synthesis of:• (±)-[1-(3-trifluoromethyl)phenyl]-2-propylamine via reductive amination reaction1• N-{2-[1-methyl-2-(3-trifluoromethylphenyl]}-aminoethanol2 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 89 °C / 192.2 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-(Trifluoromethyl)phenylacetone primarily used for?
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3-(Trifluoromethyl)phenylacetone is primarily used as a building block in organic synthesis, particularly for creating more complex molecules such as amines and heterocyclic compounds, often in pharmaceutical research.
What is the CAS number and molecular formula for 3-(Trifluoromethyl)phenylacetone?
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The CAS number is 21906-39-8, and the molecular formula is CF₃C₆H₄CH₂COCH₃.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-(Trifluoromethyl)phenylacetone with a purity of 97% (assay). This is a technical/research grade, and TSS does not represent it as USP, BP, or EP grade.
What are the safety and handling considerations for this chemical?
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This compound is classified as a Warning, with hazards including skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, such as eyeshields and gloves, should be used. Ensure adequate ventilation and avoid breathing dust/fume/gas/mist/vapours/spray. Handle in accordance with all applicable regulations.
Is this chemical suitable for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 3-(Trifluoromethyl)phenylacetone, and can arrange export.
How can I request a sample or quote for 3-(Trifluoromethyl)phenylacetone?
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To request a sample or a quote, please contact our sales team through the website or by phone, providing the product name and CAS number (21906-39-8).
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