2-Bromomethyl-1,3-dioxolane
2-Bromomethyl-1,3-dioxolane (CAS: 4360-63-8) is a valuable organic building block with the molecular formula C4H7BrO2 and a molecular weight of 167.00 g/mol. This compound serves as a key intermediate in various chemical syntheses, notably in the preparation of Grignard reagents and the development of complex organic structures like 1,4-benzoxazepine derivatives. Its acetal/ketal functionality and reactive bromomethyl group make it a versatile reagent in organic chemistry.
- IUPAC
- Bromoacetaldehyde ethylene acetal
- Synonyms
- Bromoacetaldehyde ethylene acetal
Synthesis of 1,4-Benzoxazepine Derivatives
2-Bromomethyl-1,3-dioxolane has been utilised as a crucial starting material in the synthetic pathways leading to 1,4-benzoxazepine (BZO) derivatives, a class of compounds with significant pharmacological interest.
Preparation of Grignard Reagents
This compound is employed in the laboratory for the preparation of Grignard reagents, which are essential organometallic compounds widely used in carbon-carbon bond formation reactions.
Organic Synthesis Intermediate
As a functionalised dioxolane, 2-Bromomethyl-1,3-dioxolane acts as a versatile building block in general organic synthesis, enabling the introduction of specific structural motifs into target molecules.
| Molecular weight | 167.00 |
|---|---|
| Empirical formula | C4H7BrO2 |
| Assay | 96% |
| Boiling point | 80-82 °C/27 mmHg(lit.) |
| Density | 1.613 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.482(lit.) |
| Application | 2-Bromomethyl-1,3-dioxolane was used in the synthesis of 1,4-benzoxazepine (BZO) derivatives1. It was also used in the preparation of Grignard reagent2. |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 62 °C / 143.6 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Bromomethyl-1,3-dioxolane used for?
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2-Bromomethyl-1,3-dioxolane is used as an intermediate in organic synthesis, including the preparation of Grignard reagents and the synthesis of 1,4-benzoxazepine derivatives. It is a versatile building block for introducing specific functional groups.
What are the CAS number and formula for 2-Bromomethyl-1,3-dioxolane?
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The CAS number for 2-Bromomethyl-1,3-dioxolane is 4360-63-8, and its empirical formula is C4H7BrO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Bromomethyl-1,3-dioxolane with a minimum assay of 96%. This product is typically considered a research or technical grade reagent and is not supplied as USP, BP, EP, or pharmacopoeia grade.
What are the safety and handling precautions for 2-Bromomethyl-1,3-dioxolane?
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2-Bromomethyl-1,3-dioxolane is a Warning substance that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). It is essential to use appropriate personal protective equipment, including eyeshields and gloves, and to handle it in a well-ventilated area or with respiratory protection.
Is 2-Bromomethyl-1,3-dioxolane shipped internationally?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 2-Bromomethyl-1,3-dioxolane, and can accommodate international shipping requests.
How can I request a sample or quote for 2-Bromomethyl-1,3-dioxolane?
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To request a sample or a quote for 2-Bromomethyl-1,3-dioxolane, please contact our sales department through the website or by phone, providing your specific requirements.
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