Nalidixic acid
Nalidixic acid (CAS: 389-08-2, C12H12N2O3, MW: 232.24) is a synthetic antibacterial agent and a quinolone antibiotic. It functions by inhibiting bacterial DNA gyrase, thereby interfering with DNA replication, supercoiling, and chromosome fragmentation. Primarily utilised in laboratory research for its antimicrobial properties and as a tool to study DNA replication and repair mechanisms.
- IUPAC
- 1,4-Dihydro-1-ethyl-7-methyl-1,8-naphthyridin-4-one-3-carboxylic acid,1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid
- Synonyms
- 1,4-Dihydro-1-ethyl-7-methyl-1,8-naphthyridin-4-one-3-carboxylic acid1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid
Antibacterial Research
Nalidixic acid inhibits bacterial DNA gyrase, making it a valuable tool for studying bacterial DNA replication and repair pathways in research settings.
Cell Cycle and Apoptosis Studies
This compound has been used to investigate the roles of DNA replication and integrity in cellular processes such as apoptosis and cell cycle progression.
DNA Metabolism Research
Its mechanism of action on DNA gyrase makes nalidixic acid useful for exploring various aspects of bacterial DNA metabolism.
| Molecular weight | 232.24 |
|---|---|
| Empirical formula | C12H12N2O3 |
| Assay | ≥98% |
| Solubility | chloroform: soluble20 mg/mL, clear |
| Application | Used to modulate (inhibit) bacterial DNA gyrase-dependent processes such as DNA polymerization, (ATP-dependen)t DNA supercoiling, and chromosome fragmentation. |
| Melting point | 227-229 °C(lit.) |
Hazard statements
- H334May cause allergy or asthma symptoms if inhaled
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P342
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 42/43 |
| Safety statements (S) | 22-36/37-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Nalidixic acid used for?
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Nalidixic acid is primarily used in laboratory research to inhibit bacterial DNA gyrase, thereby affecting DNA replication, supercoiling, and chromosome fragmentation. It serves as a tool for studying antibacterial mechanisms, DNA metabolism, and cell cycle processes.
What are the CAS number and formula for Nalidixic acid?
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The CAS number for Nalidixic acid is 389-08-2 and its empirical formula is C12H12N2O3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Nalidixic acid with an assay of ≥98%. This product is intended for research and laboratory use and is not represented as USP, BP, EP, or other pharmacopoeia grades.
How should Nalidixic acid be handled?
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Handle Nalidixic acid with appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, face shields, and gloves. Ensure good ventilation. Avoid breathing dust. In case of inhalation, move to fresh air and seek medical attention if symptoms persist. For specific guidance, refer to the Safety Data Sheet.
How is Nalidixic acid packed and exported?
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Nalidixic acid is carefully packed to ensure stability during transit and is exported globally by Tech Serve Solutions, adhering to all relevant shipping regulations for chemicals.
How can I request a sample or quote for Nalidixic acid?
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To request a sample or obtain a quote for Nalidixic acid, please contact our sales department through the website or by phone, providing your contact details and the quantity required.
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