NU7026

CAS 154447-35-5C17H15NO3Biochemicals & Reagents

NU7026 (CAS: 154447-35-5) is a chemical compound with the molecular formula C17H15NO3 and a molecular weight of 281.31 g/mol. This tan solid is a potent, ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK). It exhibits significant selectivity over other PI3K-related kinases. NU7026 is primarily utilised in biochemical research as a tool to study DNA repair pathways and related cellular processes.

IUPAC: 2-(Morpholin-4-yl)-benzo[h]chromen-4-one

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NU7026 (C17H15NO3) — chemical structure, CAS 154447-35-5; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesBiochemicals and ReagentsCell BiologyEnzyme InhibitorsEnzyme Inhibitors by EnzymeEnzymesInhibitorsand SubstratesKinase/Phosphatase BiologyP to Q

01 /Applications

DNA-PK Inhibition

NU7026 serves as a selective inhibitor of DNA-dependent protein kinase (DNA-PK), with an IC50 of 0.23 μM. Its potency and selectivity make it valuable for research into DNA repair mechanisms and associated cellular signalling.

Cellular Research Tool

Utilised in cell biology studies to investigate the role of DNA-PK in cellular responses to DNA damage. Its application aids in understanding cell cycle regulation and apoptosis pathways.

Biochemical Assays

Employed in biochemical assays to characterise kinase activity and screen for modulators of the DNA-PK pathway. Its well-defined inhibitory profile ensures reliable experimental outcomes.

02 /Properties

Molecular weight	281.31
Empirical formula	C17H15NO3
Assay	≥98% (HPLC)
Form	solid
Colour	tan
Solubility	DMSO: soluble3 mg/mL at 60 °CH2O: insoluble
Storage temperature	2-8°C
Application	Potent, ATP-competitive. IC50 = 0.23 μM. Selectivity over other PI3K-related kinases (IC50 = 13 μM for PI3K and >100 μM for ATM and ATR).

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

154447-35-5

MDL number

MFCD06798345

05 /Additional specifications

Shipped In	wet ice

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is NU7026 used for?

NU7026 is a potent, ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK), used in biochemical research to study DNA repair pathways and related cellular processes.

What is the CAS number and formula for NU7026?

The CAS number for NU7026 is 154447-35-5, and its molecular formula is C17H15NO3.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies NU7026 with a purity of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade.

How should NU7026 be handled and stored?

NU7026 should be handled using appropriate personal protective equipment including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Store at 2-8°C. It is also noted as WGK Germany 3, indicating a higher hazard level.