NS-398
NS-398 (CAS: 123653-11-2), a chemical compound with the formula C13H18N2O5S and a molecular weight of 314.36, presents as an off-white solid. It is recognised for its role as a selective cyclooxygenase-2 (COX-2) inhibitor. This compound finds utility in research settings for investigating inflammatory pathways and is employed in studies related to cancer research and cell biology, contributing to the understanding of enzyme inhibition mechanisms.
- IUPAC
- N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide
Selective COX-2 Inhibition
NS-398 is primarily utilised as a research tool to selectively inhibit cyclooxygenase-2 (COX-2) activity. This allows scientists to study the specific roles of COX-2 in various biological processes without the confounding effects of COX-1 inhibition.
Cancer Research Investigations
The compound is applied in cancer research to explore the potential involvement of COX-2 in tumour development and progression. Its inhibitory action can help elucidate therapeutic strategies targeting the arachidonic acid cascade.
Cell Biology Studies
In cell biology, NS-398 is used to investigate cellular signaling pathways influenced by COX-2. This aids in understanding the mechanisms of inflammation and cell proliferation at a molecular level.
Pharmacological Research
As a specific enzyme inhibitor, NS-398 serves as a valuable reagent for pharmacological studies, contributing to the development of new agents that modulate inflammatory responses and related physiological functions.
| Molecular weight | 314.36 |
|---|---|
| Empirical formula | C13H18N2O5S |
| Assay | ≥98% (HPLC) |
| Form | solid |
| Colour | off-white |
| Solubility | DMSO: >5 mg/mLH2O: insoluble |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... ALOX5(240), CYP19A1(1588), PTGS1(5742), PTGS2(5743)mouse ... Ptgs2(19225) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is NS-398 used for?
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NS-398 is primarily used in research for its selective inhibition of cyclooxygenase-2 (COX-2), making it valuable for studies in cancer research, cell biology, and investigating inflammatory pathways.
What is the CAS number and formula for NS-398?
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The CAS number for NS-398 is 123653-11-2, and its empirical formula is C13H18N2O5S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies NS-398 with a purity of ≥98% by HPLC. This product is intended for research and laboratory use and is not represented as USP, BP, EP, or any other pharmacopoeial grade.
What are the safety considerations when handling NS-398?
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When handling NS-398, appropriate personal protective equipment, including eyeshields and gloves, is essential. A type N95 (US) or type P1 (EN143) respirator filter should be used. The compound is classified with a WGK Germany rating of 3, indicating it is hazardous to water.
How is NS-398 packed, shipped, and exported?
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NS-398 is typically supplied as an off-white solid. Tech Serve Solutions complies with all relevant regulations for packing, shipping, and exporting chemical compounds globally.
How can I request a sample or quote for NS-398?
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To request a sample or a quote for NS-398, please contact the Tech Serve Solutions sales team through our official website or designated contact channels.
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