NIR-797 isothiocyanate
NIR-797 isothiocyanate (CAS: 152111-91-6), a complex organic compound with the formula C45H50N3NaO6S4 and a molecular weight of 880.14 g/mol, is a specialised fluorescent labelling reagent. It is primarily used for the in vivo characterisation of nanoparticles via near-infrared fluorescence imaging by reacting with hydroxyl end groups. Its applications extend to enhancing cancer imaging and treatment when bound to PEGylated compounds.
- IUPAC
- 1,1′-Bis(4-sulfobutyl)-11-(4-isothiocyanatophenylthio)-3,3,3′,3′-tetramethyl-10,12-tri methyleneindotricarbocyanine monosodium salt
Nanoparticle Labelling for In Vivo Imaging
NIR-797 isothiocyanate reacts with hydroxyl end groups on nanoparticles, enabling their real-time biodistribution characterisation using non-invasive, near-infrared fluorescence imaging.
Photosignal Enhancement in Nano-materials
This compound acts as a photosignal enhancer on the surface of nano-materials, facilitating the detection of various analytes.
Cancer Imaging and Treatment Enhancement
When conjugated to polyethylene glycol (PEG) or PEGylated compounds, NIR-797 isothiocyanate can enhance targeted cancer imaging and therapeutic strategies.
| Molecular weight | 880.14 |
|---|---|
| Empirical formula | C45H50N3NaO6S4 |
| Assay | ≥70% (coupling to amines) |
| Storage temperature | 2-8°C |
| Application | NIR-797 isothiocyanate reacts with hydroxyl end groups to label nanoparticles, which allows for in vivo real-time biodistribution characterization using non-invasive, near-infrared fluorescence imaging 1. A photosignal enhancer on the surface of nano-materials which are used to detect various analytes 2,3. Bound to PEG or PEGylated compounds to enhance cancer imaging and treatment 4,5. |
| Suitability | suitable for fluorescence |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Fluorescence | λex 795 nm; λem 817 nm in 0.1 M phosphate pH 7.0 |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is NIR-797 isothiocyanate used for?
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NIR-797 isothiocyanate is primarily used for labelling nanoparticles to enable in vivo real-time biodistribution characterisation via near-infrared fluorescence imaging. It also functions as a photosignal enhancer on nano-materials for analyte detection and is used to enhance cancer imaging and treatment when bound to PEGylated compounds.
What are the CAS number and formula for NIR-797 isothiocyanate?
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The CAS number for NIR-797 isothiocyanate is 152111-91-6, and its empirical formula (Hill notation) is C45H50N3NaO6S4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies NIR-797 isothiocyanate with an assay of ≥70% (coupling to amines). We do not represent this product as USP, BP, EP, or other pharmacopoeial grades.
What safety precautions should be taken when handling NIR-797 isothiocyanate?
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When handling NIR-797 isothiocyanate, it is essential to use appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. The compound has a WGK Germany rating of 3, indicating a high hazard to water.
How is NIR-797 isothiocyanate shipped and exported?
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NIR-797 isothiocyanate is typically stored at 2-8°C. Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, capable of handling international shipments.
How can I request a quote or sample for NIR-797 isothiocyanate?
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To request a quote or sample for NIR-797 isothiocyanate, please contact our sales department through the TSS website or by telephone.
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