Naloxone hydrochloride dihydrate
Naloxone hydrochloride dihydrate (CAS: 51481-60-8), with the molecular formula C19H21NO4 · HCl · 2H2O and a molecular weight of 399.87 g/mol, is a critical opioid antagonist. This white to off-white powder is primarily recognised for its role in reversing the effects of opioid overdose. It serves as an important reagent in biochemical research, particularly in studies involving cell signaling and neuroscience, and is classified as an approved therapeutic.
Opioid Overdose Reversal
Naloxone is a widely used emergency medication for the rapid reversal of opioid overdose. It competitively binds to opioid receptors, displacing agonists and restoring normal respiration and consciousness.
Neuroscience Research
As a specific opioid antagonist, it is extensively employed in research settings to investigate the roles of opioid receptors (OPRD1, OPRK1, OPRM1, OPRS1) in various physiological and pathological processes within the central nervous system.
Biochemical Studies
Utilized in biochemical assays and cell biology experiments to understand receptor-ligand interactions and downstream signaling pathways modulated by the opioid system.
| Molecular weight | 399.87 |
|---|---|
| Empirical formula | C19H21NO4 · HCl · 2H2O |
| Assay | ≥98% (TLC and titration) |
| Form | powder |
| Colour | white to off-white |
| Solubility | ethanol: soluble3.3 mg/mL (stable for several months refrigerated if protected from light.)H2O: soluble50 mg/mL (stable for several months refrigerated if protected from light.) |
| Optical activity | [α]25/D −178.6°, c = 2.5 in H2O(lit.) |
| Storage temperature | 2-8°C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 22-26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... OPRD1(4985), OPRK1(4986), OPRM1(4988), OPRS1(10280) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Naloxone hydrochloride dihydrate used for?
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Naloxone hydrochloride dihydrate is primarily used to reverse the effects of opioid overdose and is a valuable tool in neuroscience and biochemical research for studying opioid receptor function.
What is the CAS number and formula for Naloxone hydrochloride dihydrate?
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The CAS number is 51481-60-8, and the empirical formula is C19H21NO4 · HCl · 2H2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Naloxone hydrochloride dihydrate with an assay of ≥98% (TLC and titration). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated.
How should Naloxone hydrochloride dihydrate be handled safely?
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Handle with appropriate personal protective equipment, including a dust mask type N95, eyeshields, and gloves. Avoid breathing dust and ensure adequate ventilation. This compound is a warning substance that can cause skin irritation, serious eye irritation, and respiratory irritation (H315-H319-H335).
Is Naloxone hydrochloride dihydrate a controlled substance?
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While naloxone itself is an opioid antagonist, its regulatory status can vary. Please consult your local regulations regarding its procurement and handling.
How is Naloxone hydrochloride dihydrate packed and shipped?
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Naloxone hydrochloride dihydrate is carefully packed to maintain its integrity during transit and is available for global export by Tech Serve Solutions.
How can I request a quote or sample?
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To request a quote or sample of Naloxone hydrochloride dihydrate, please contact our sales team through our website or by phone.
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