N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide

CAS 77377-52-7CF3CON(CH3)Si(CH3)2C(CH3)3Biochemicals & Reagents

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide (CAS: 77377-52-7; Formula: CF3CON(CH3)Si(CH3)2C(CH3)3) is a silylating agent with a molecular weight of 241.33 g/mol. It is primarily utilised in analytical chemistry for the derivatisation of compounds to enhance their volatility and detectability in chromatographic techniques. This reagent is crucial for sample preparation in gas chromatography (GC) and other analytical methods requiring the conversion of polar functional groups into more stable, volatile derivatives.

IUPAC: MTBSTFA
Synonyms: MTBSTFA

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N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide (CF3CON(CH3)Si(CH3)2C(CH3)3) — chemical structure, CAS 77377-52-7; Life Science, fine chemical supplied by Tech Serve Solutions

Analytical ReagentsAnalytical/ChromatographyBiochemicals and ReagentsChemical SynthesisDerivatization ReagentsDerivatization Reagents GCReagents for SilylationScintillation ReagentsScintillation reagents

01 /Applications

Gas Chromatography Derivatisation

This compound is employed as a derivatising agent to improve the gas chromatographic analysis of various analytes. It reacts with active hydrogen atoms to form stable, volatile trimethylsilyl derivatives, facilitating their separation and detection.

Analytical Reagent

It serves as a valuable reagent in analytical laboratories for sample preparation. Its ability to silylate functional groups makes it useful for enhancing the detectability of compounds in techniques such as GC-MS.

Chemical Synthesis

Utilised in organic synthesis as a protecting group reagent. The tert-butyldimethylsilyl (TBDMS) group can be selectively introduced and removed, offering a versatile tool in multi-step synthetic pathways.

Silylation Agent

As a specialised silylating agent, it offers a convenient method for introducing the TBDMS group, particularly for compounds that are otherwise difficult to analyse or react. The trifluoroacetamide moiety enhances reactivity.

02 /Properties

Molecular weight	241.33
Linear formula	CF3CON(CH3)Si(CH3)2C(CH3)3
Assay	>97%
Boiling point	172-175 °C(lit.)
Density	1.036 g/mL at 25 °C(lit.)
Refractive index	n20/D 1.402(lit.)
Storage temperature	2-8°C
Contains / stabiliser	1% TBDMSCl

03 /Safety & handling

GHS hazard pictogram: Flammable (GHS02) — Flammable

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES

Protective equipment	Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Flash point	45 °C / 113 °F
Transport (UN / ADR)	UN 1993C 3 / PGIII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xi
Risk statements (R)	10-36/37/38
Safety statements (S)	26

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

77377-52-7

MDL number

MFCD00009671

Beilstein registry

3606546

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide used for?

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide (CAS 77377-52-7) is primarily used as a derivatising agent in analytical chemistry, particularly for gas chromatography, to increase the volatility and detectability of various compounds by silylation.

What are the CAS number and chemical formula for N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide?

The CAS number is 77377-52-7, and the chemical formula is CF3CON(CH3)Si(CH3)2C(CH3)3.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this chemical with an assay of >97%. We do not represent this product as USP, BP, EP, or pharmacopoeia grade.

How should N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide be handled safely?

This compound is flammable (flash point 45°C) and can cause skin, eye, and respiratory irritation (H226-H315-H319-H335). Always use appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, and ensure adequate ventilation. Store at 2-8°C.

How is this chemical packed, shipped, and exported?

Tech Serve Solutions packages and ships chemicals in compliance with all relevant national and international regulations. We export globally, ensuring secure and compliant transit.