N-(5-Chloro-pyridin-3-yl)-2,2-dimethyl-propionamide
N-(5-Chloro-pyridin-3-yl)-2,2-dimethyl-propionamide (CAS 879326-78-0; molecular formula C10H13ClN2O; molar mass 212.68 g/mol) is a halogenated pyridine building block in which a 3-aminopyridine bearing a 5-chloro substituent is acylated with a pivaloyl (2,2-dimethylpropanoyl) group. Supplied as a research-grade solid, it serves chiefly as an intermediate in pharmaceutical and fine-chemical synthesis, where the chloro handle and the pivaloamide support regioselective functionalisation and metal-catalysed cross-coupling.
- Synonyms
- N-(5-Chloro-pyridin-3-yl)-2,2-dimethyl-propionamideN-(5-Chloropyridin-3-yl)pivalamideN-(5-Chloro-3-pyridinyl)-2,2-dimethylpropanamide2,2-Dimethyl-N-(5-chloropyridin-3-yl)propanamideCAS 879326-78-0C10H13ClN2O
Pharmaceutical and fine-chemical intermediate
Used as a heterocyclic building block in multistep synthesis toward pharmaceutically relevant pyridine scaffolds. The substituted aminopyridine core is a recurring motif in medicinal-chemistry programmes.
Cross-coupling substrate
The aromatic chloro substituent provides a reactive site for palladium- or nickel-catalysed cross-coupling reactions, enabling the introduction of aryl, heteroaryl and other groups onto the pyridine ring.
Pivaloamide directing and protecting group
The bulky pivaloyl amide is a well-established protecting group for the pyridyl amine and can direct regioselective C-H functionalisation and directed metalation in heterocyclic chemistry.
Research and discovery chemistry
Employed in laboratory-scale exploratory synthesis and library preparation where a defined chloro-pyridine amide intermediate is required for further elaboration.
| Molecular weight | 212.68 |
|---|---|
| Empirical formula | C10H13ClN2O |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(5-Chloro-pyridin-3-yl)-2,2-dimethyl-propionamide used for?
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It is used primarily as a halogenated pyridine building block and synthetic intermediate in pharmaceutical and fine-chemical research. The reactive chloro substituent supports metal-catalysed cross-coupling, while the pivaloyl amide protects the amine and can direct regioselective functionalisation of the ring.
What is the CAS number and molecular formula of N-(5-Chloro-pyridin-3-yl)-2,2-dimethyl-propionamide?
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Its CAS number is 879326-78-0. The molecular formula is C10H13ClN2O (Hill notation), corresponding to a molecular weight of 212.68 g/mol.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound as a research- and technical-grade material for synthesis and laboratory use. We do not represent it as a USP, BP or EP pharmacopoeial grade. A current Certificate of Analysis stating the assay and specification for each batch is available on request.
How should N-(5-Chloro-pyridin-3-yl)-2,2-dimethyl-propionamide be handled and stored?
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Handle as a research chemical using good laboratory practice: wear suitable gloves and eye protection, work in a well-ventilated area or fume hood, and avoid generating dust. Store in a tightly closed container in a cool, dry place away from incompatible materials. As no specific GHS classification is provided with this batch, treat the substance as potentially hazardous and consult the Safety Data Sheet supplied with the order before use.
How is N-(5-Chloro-pyridin-3-yl)-2,2-dimethyl-propionamide packed, shipped and exported?
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It is packed in sealed, appropriately labelled containers sized to the order, from gram quantities to larger research lots, with secondary protection for transit. As a specialist exporter, Tech Serve Solutions arranges compliant international shipping and the accompanying documentation, including a Safety Data Sheet and Certificate of Analysis.
How do I request a sample or a quote?
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Contact Tech Serve Solutions with the product name or CAS 879326-78-0 and your required quantity and specification. We will respond with availability, lead time, documentation and a formal quotation, and can arrange a sample where appropriate.
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