N-(5-Iodo-3-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide
N-(5-Iodo-3-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide (CAS 677327-29-6; molecular formula C11H15IN2O; molar mass 318.15 g/mol) is a halogenated pyridine building block in which a 2-aminopyridine is protected as its pivalamide and carries an iodine at the 5-position and a methyl at the 3-position. The aryl iodide and the directing pivaloyl group make it a versatile intermediate for metal-catalysed cross-coupling and regioselective functionalisation in pharmaceutical and fine-chemical research. Tech Serve Solutions supplies it as a research-grade intermediate.
- Synonyms
- N-(5-Iodo-3-methyl-pyridin-2-yl)-2,2-dimethyl-propionamideN-(5-Iodo-3-methylpyridin-2-yl)pivalamideN-(5-iodo-3-methylpyridin-2-yl)-2,2-dimethylpropanamide2,2-dimethyl-N-(5-iodo-3-methylpyridin-2-yl)propanamideCAS 677327-29-6
Cross-coupling building block
The 5-iodo substituent serves as a reactive handle for palladium- or copper-catalysed cross-coupling reactions such as Suzuki-Miyaura, Sonogashira, Negishi and Buchwald-Hartwig amination, enabling carbon-carbon and carbon-heteroatom bond formation on the pyridine ring.
Pivalamide-protected aminopyridine intermediate
The pivaloyl (2,2-dimethylpropanoyl) group protects the 2-amino function and can act as a directing group for regioselective metalation; it can be removed by hydrolysis to reveal the free aminopyridine for further elaboration.
Pharmaceutical and medicinal-chemistry research
Substituted iodopyridines of this type are used as scaffolds in discovery chemistry to assemble more complex heterocyclic structures and analogue libraries. Specific therapeutic uses should be defined by the end user's own programme.
Heterocyclic synthesis and library design
As a defined C11 halogenated heterocyclic building block, it supports the construction of functionalised pyridine cores for agrochemical, materials and general fine-chemical synthesis.
| Molecular weight | 318.15 |
|---|---|
| Empirical formula | C11H15IN2O |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(5-Iodo-3-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide used for?
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It is used mainly as a synthetic building block. The aryl iodide is a handle for palladium- and copper-catalysed cross-coupling, while the pivalamide protects and can direct functionalisation of the 2-aminopyridine, making the compound useful for preparing more complex pyridine derivatives in pharmaceutical and fine-chemical research.
What is the CAS number and molecular formula of N-(5-Iodo-3-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide?
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Its CAS number is 677327-29-6 and its molecular formula is C11H15IN2O, with a molecular weight of approximately 318.15 g/mol (empirical formula in Hill notation: C11H15IN2O).
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound as a research-grade synthesis intermediate. A specific assay value is confirmed against the batch certificate of analysis at the time of order. We do not represent it as USP, BP or EP pharmacopoeial grade; please request current specifications for your application.
How should N-(5-Iodo-3-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide be handled and stored?
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Detailed GHS hazard classification is not included in the supplied data, so handle it as a research chemical of undetermined hazard. Use appropriate personal protective equipment, work with good ventilation, avoid contact and inhalation, and store the sealed container cool and dry away from light and incompatible materials. Always refer to the accompanying Safety Data Sheet before use.
How is the compound packed, shipped and exported?
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It is packed in suitably sealed, labelled containers sized to the order, from gram research quantities upward, with packaging chosen to protect a light-sensitive solid. Tech Serve Solutions exports worldwide with full documentation and a certificate of analysis, in line with applicable transport and customs requirements.
How do I request a sample or quote?
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Contact Tech Serve Solutions with the product name or CAS number 677327-29-6 and your required quantity and purity. We will respond with current specifications, available pack sizes, lead time and a formal quotation, and can arrange a sample where appropriate.
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