N-(4-Hydroxy-5-((trimethylsilyl)ethynyl)pyridin-3-yl)acetamide
N-(4-Hydroxy-5-((trimethylsilyl)ethynyl)pyridin-3-yl)acetamide (CAS 1203499-31-3) is a functionalised pyridine building block with the molecular formula C12H16N2O2Si and a molecular weight of 248.35 g/mol. The molecule combines an acetamido-hydroxypyridine core with a trimethylsilyl (TMS) protected alkyne, making it a versatile intermediate for chemical synthesis and medicinal-chemistry research. Tech Serve Solutions supplies it as a research-grade heterocyclic reagent to laboratories and process chemists worldwide.
- Synonyms
- N-(4-Hydroxy-5-((trimethylsilyl)ethynyl)pyridin-3-yl)acetamideN-[4-hydroxy-5-(2-trimethylsilylethynyl)pyridin-3-yl]acetamideN-(4-hydroxy-5-((trimethylsilyl)ethynyl)pyridin-3-yl)acetamideCAS 1203499-31-3
Heterocyclic building block
Serves as a multi-functional pyridine scaffold in chemical synthesis, offering hydroxy, acetamido and silyl-alkyne handles for selective, sequential transformations.
TMS-protected alkyne intermediate
The trimethylsilyl group protects the terminal alkyne during synthesis and can be removed under mild conditions to reveal a free terminal alkyne for further coupling.
Sonogashira and click-chemistry precursor
After desilylation, the liberated terminal alkyne is well suited to palladium-catalysed Sonogashira couplings and copper-catalysed azide-alkyne cycloadditions for building extended molecular frameworks.
Medicinal-chemistry research
Used in discovery laboratories as an intermediate towards more complex pyridine-based targets. Tech Serve Solutions supplies it for research and development use only.
| Molecular weight | 248.35 |
|---|---|
| Empirical formula | C12H16N2O2Si |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(4-Hydroxy-5-((trimethylsilyl)ethynyl)pyridin-3-yl)acetamide used for?
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It is used primarily as a building block and intermediate in chemical synthesis and medicinal-chemistry research. The protected alkyne, hydroxy and acetamido groups allow selective transformations, including Sonogashira couplings and click chemistry once the trimethylsilyl group is removed.
What is the CAS number and molecular formula of N-(4-Hydroxy-5-((trimethylsilyl)ethynyl)pyridin-3-yl)acetamide?
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The CAS number is 1203499-31-3. The molecular formula is C12H16N2O2Si (Hill notation) with a molecular weight of 248.35 g/mol.
What grade and purity does Tech Serve Solutions supply?
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We supply this compound as a research/technical-grade reagent for laboratory and synthesis use. The specific assay is confirmed on the batch Certificate of Analysis supplied with each order. We do not represent it as USP, BP or EP pharmacopoeial grade.
How should this compound be handled and stored?
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No specific GHS hazard classification is provided in our current data, so it should be handled as a research chemical of unknown hazard: use appropriate laboratory PPE, work in a fume hood and avoid dust, skin and eye contact. Store tightly closed in a cool, dry, well-ventilated place. Always consult the Safety Data Sheet supplied with the product before use.
How is N-(4-Hydroxy-5-((trimethylsilyl)ethynyl)pyridin-3-yl)acetamide packed, shipped and exported?
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It is packed in appropriately sealed laboratory containers sized to your order, from gram to bulk quantities, with full labelling and documentation. As a specialist exporter since 1998, Tech Serve Solutions arranges compliant international shipping with the relevant Certificate of Analysis and Safety Data Sheet.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, purity and destination, and our team will respond with availability, lead time and a formal quotation. Samples can be discussed for qualified research and commercial enquiries.
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