N-(4-Aminophenyl)piperidine
N-(4-Aminophenyl)piperidine is an aromatic amine building block (CAS 2359-60-6; molecular formula C11H16N2; molar mass 176.26 g/mol) comprising a piperidine ring N-linked to a para-aminophenyl group. Supplied as a research-grade solid of 97% assay, it is a versatile heterocyclic intermediate in chemical and pharmaceutical synthesis, valued as a reactant for amino acid arylamides and a range of medicinally relevant scaffolds. Tech Serve Solutions supplies and exports it worldwide to laboratory and manufacturing customers.
- IUPAC
- 4-(1-Piperidino)aniline,4-(1-Piperidinyl)-benzemamine
- Synonyms
- N-(4-Aminophenyl)piperidine4-(1-Piperidino)aniline4-(1-Piperidinyl)benzenamine4-(Piperidin-1-yl)aniline1-(4-Aminophenyl)piperidine4-Piperidinoaniline
Pharmaceutical and medicinal chemistry intermediate
Serves as a reactant in the synthesis of selective interleukin-2 inducible T-cell kinase inhibitors and IRAK-4 inhibitors. The reactive primary aromatic amine offers a convenient handle for amide formation and further functionalisation.
Amino acid arylamide synthesis
Used as a building block for amino acid arylamides, where the aniline nitrogen is acylated to construct the arylamide linkage. This supports the preparation of peptide-mimetic and conjugate structures.
Antimalarial and antiviral research compounds
Documented as a reactant toward antimalarial drug candidates and aglycoristocetin derivatives investigated for anti-influenza virus activity. It is employed at the discovery and route-development stage.
Heterocyclic and acridine scaffolds
Applied in the preparation of 9-aminoacridines reported to show antiprion activity, and more broadly as a piperidine-bearing building block for assembling nitrogen-rich heterocyclic systems.
General research-scale organic synthesis
Functions as a bifunctional intermediate combining a secondary amine (piperidine) and a primary aromatic amine, useful for cross-coupling, reductive amination and condensation chemistry in laboratory programmes.
| Molecular weight | 176.26 |
|---|---|
| Empirical formula | C11H16N2 |
| Assay | 97% |
| Refractive index | n20/D 1.5937(lit.) |
| Storage temperature | 2-8°C |
| Application | Reactant for synthesis of:• Amino acid arylamides1• Selective interleukin-2 inducible T-cell inhibitors2• Antimalarial drugs3• Aglycoristocetin derivatives for anti-influenza virus activity4• IRAK-4 inhibitors5• 9-Aminoacridines with antiprion activity6 |
| Melting point | 26-29 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(4-Aminophenyl)piperidine used for?
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It is used principally as a synthetic building block and reactant in chemical and pharmaceutical research. Documented uses include the synthesis of amino acid arylamides, selective ITK inhibitors, IRAK-4 inhibitors, antimalarial candidates, aglycoristocetin derivatives studied for anti-influenza activity, and 9-aminoacridines with antiprion activity.
What is the CAS number and molecular formula of N-(4-Aminophenyl)piperidine?
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Its CAS number is 2359-60-6 and its molecular formula is C11H16N2, with a molecular weight of 176.26 g/mol. The MDL number is MFCD00051688 and the PubChem Substance ID is 24879568.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N-(4-Aminophenyl)piperidine as a research/technical-grade solid with a typical assay of 97%. We do not represent it as USP, BP or EP pharmacopoeia grade. Indicative physical data include a melting point of 26-29 °C and a refractive index of n20/D 1.5937; recommended storage is 2-8 °C.
What are the safety and handling requirements?
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It is classified under GHS07 with the signal word Warning and hazard statements H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Handle with eye protection and gloves, use a dust mask (type N95) where dust may form, and follow precautionary statements P261 and P305+P351+P338. The German Water Hazard Class (WGK) is 3, indicating it is severely hazardous to water; prevent release to the environment. Always consult the Safety Data Sheet before use.
How is N-(4-Aminophenyl)piperidine packed, shipped and exported?
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It is packed in appropriately sealed, labelled containers sized to the order and suited to its irritant classification, with cool storage (2-8 °C) recommended. Tech Serve Solutions ships and exports worldwide with full documentation, including a Certificate of Analysis and Safety Data Sheet; packaging and transport are arranged to meet applicable regulations for the destination.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, purity and destination, and our team will respond with availability, lead time and documentation. We can quote research quantities through to larger commercial volumes for export.
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