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N-(4-Hydroxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide

CAS 551950-45-9C11H16N2O2Heterocyclic Building Blocks

N-(4-Hydroxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide (CAS 551950-45-9; C11H16N2O2; molar mass 208.26 g/mol) is a heterocyclic building block for organic and pharmaceutical synthesis. The molecule combines a 2-aminopyridine protected as its pivalamide (2,2-dimethylpropionamide) with a 4-hydroxymethyl handle, giving two orthogonal sites for further functionalisation. Tech Serve Solutions supplies it as a research-grade fine chemical to laboratories and process-development groups worldwide.

Synonyms
N-(4-Hydroxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamideN-[4-(Hydroxymethyl)pyridin-2-yl]-2,2-dimethylpropanamideN-[4-(Hydroxymethyl)-2-pyridinyl]-2,2-dimethylpropanamide2,2-Dimethyl-N-[4-(hydroxymethyl)pyridin-2-yl]propanamideCAS 551950-45-9C11H16N2O2
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N-(4-Hydroxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide (C11H16N2O2) — chemical structure, CAS 551950-45-9; Chemistry, fine chemical supplied by Tech Serve Solutions
Building BlocksC11Chemical SynthesisHeterocyclic Building BlocksPyridines
01 /Applications

Pyridine building block

Serves as a substituted 2-aminopyridine scaffold for assembling more complex heterocyclic targets. The pre-installed pivalamide and hydroxymethyl groups shorten multi-step routes in discovery and medicinal chemistry.

Protected aminopyridine intermediate

The 2,2-dimethylpropionamide (pivaloyl) group masks the ring amine during downstream reactions and can be removed under hydrolytic conditions to reveal the free 2-aminopyridine when required.

Hydroxymethyl handle for derivatisation

The primary benzylic-type alcohol at the 4-position is a versatile point for oxidation, esterification, etherification or conversion to a leaving group, enabling chain extension and further coupling.

Directed functionalisation and cross-coupling

Pivalamide-directed metalation and related cross-coupling strategies allow selective elaboration of the pyridine ring, supporting the preparation of pharmaceutical intermediates and ligand frameworks.

Research and process development

Used at laboratory and pilot scale for route scouting, structure-activity studies and reference-compound preparation where a defined, reproducible pyridine intermediate is needed.

02 /Properties
Molecular weight208.26
Empirical formulaC11H16N2O2
03 /Identifiers & registry
CAS number
551950-45-9
04 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

05 /Frequently asked questions

What is N-(4-Hydroxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide used for?

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It is used as a heterocyclic building block and protected aminopyridine intermediate in organic and pharmaceutical synthesis. Its pivalamide group and 4-hydroxymethyl handle provide two orthogonal sites for selective functionalisation, cross-coupling and chain extension in research and process-development work.

What is the CAS number and molecular formula of N-(4-Hydroxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide?

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The CAS number is 551950-45-9 and the empirical formula is C11H16N2O2 (Hill notation), corresponding to a molecular weight of 208.26 g/mol. It is a pivaloyl-protected 2-aminopyridine bearing a hydroxymethyl substituent at the 4-position.

What grade and purity does Tech Serve Solutions supply?

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We supply this compound as a research/technical-grade fine chemical intended for synthesis and laboratory use. We do not represent it as USP, BP or EP pharmacopoeial grade. A current specification and certificate of analysis, including the assayed purity of the available lot, are provided on request with each enquiry.

How should N-(4-Hydroxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide be handled and stored?

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No harmonised GHS classification is included in our supplied data for this item, so it is offered for professional laboratory use only. Handle it as a research chemical of undetermined hazard: use suitable protective gloves, eye protection and local exhaust ventilation, avoid dust, contact and ingestion, and store in a tightly closed container in a cool, dry, well-ventilated place. Always review the accompanying safety data sheet before use.

How is N-(4-Hydroxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide packed, shipped and exported?

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It is packed in sealed, labelled containers sized to the order, from gram quantities to bulk research requirements, with full identity and batch documentation. As a specialist exporter, Tech Serve Solutions arranges compliant international dispatch with the relevant transport and customs paperwork for your destination.

How do I request a sample or quote?

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Contact Tech Serve Solutions with your required quantity, purity and destination, quoting CAS 551950-45-9 or product code 115101. We will confirm current specification, availability, lead time and export terms, and can arrange a sample where appropriate.

Need N-(4-Hydroxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide in a specific grade or volume?