N-(4-Iodo-2-methoxypyridin-3-yl)pivalamide
N-(4-Iodo-2-methoxypyridin-3-yl)pivalamide (CAS 131653-62-8) is a halogenated pyridine building block with the molecular formula C11H15IN2O2 and a molar mass of 334.15 g/mol. It pairs a reactive 4-iodo substituent with a 2-methoxy group and a pivaloyl-protected 3-amino function on the pyridine ring, making it a versatile intermediate for directed metalation and transition-metal-catalysed cross-coupling in pharmaceutical and fine-chemical synthesis. Tech Serve Solutions supplies it as a research-grade intermediate to laboratory and process users worldwide.
- Synonyms
- N-(4-Iodo-2-methoxypyridin-3-yl)pivalamideN-(4-iodo-2-methoxy-3-pyridinyl)-2,2-dimethylpropanamide2,2-dimethyl-N-(4-iodo-2-methoxypyridin-3-yl)propanamideN-(4-iodo-2-methoxypyridin-3-yl)-2,2-dimethylpropanamideCAS 131653-62-8
Cross-coupling intermediate
The carbon-iodine bond at the 4-position is a convenient handle for palladium- or nickel-catalysed couplings such as Suzuki-Miyaura, Negishi, Sonogashira and related reactions, allowing controlled introduction of aryl, alkenyl and alkynyl groups onto the pyridine ring.
Pharmaceutical building block
As a substituted aminopyridine scaffold, it serves as a building block in the synthesis of pharmaceutical intermediates and candidate molecules, where the pyridine core is a common pharmacophore.
Protected aminopyridine for multistep synthesis
The pivalamide group masks the 3-amino function as a robust, sterically hindered amide that tolerates many reaction conditions and can be removed later, supporting selective transformations in multistep routes.
Directed functionalisation of pyridines
The amide and methoxy substituents can act as directing and modulating groups in regioselective metalation and further elaboration of the heterocyclic core.
Research and discovery chemistry
It is used in medicinal-chemistry and process-development laboratories for library synthesis and structure-activity studies built around the halogenated pyridine framework.
| Molecular weight | 334.15 |
|---|---|
| Empirical formula | C11H15IN2O2 |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(4-Iodo-2-methoxypyridin-3-yl)pivalamide used for?
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It is used mainly as a synthetic building block and intermediate. The reactive 4-iodo group enables transition-metal-catalysed cross-coupling, while the pivaloyl-protected amino and methoxy substituents support regioselective functionalisation of the pyridine ring in pharmaceutical and fine-chemical synthesis.
What is the CAS number and molecular formula of N-(4-Iodo-2-methoxypyridin-3-yl)pivalamide?
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Its CAS number is 131653-62-8 and its molecular formula is C11H15IN2O2, corresponding to a molecular weight of 334.15 g/mol.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound as a research- and technical-grade synthetic intermediate. We do not represent it as USP, BP or EP pharmacopoeial grade. A current specification and certificate of analysis with the exact assay can be provided on request for each batch.
How should N-(4-Iodo-2-methoxypyridin-3-yl)pivalamide be handled and stored?
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Handle it as a research chemical using standard laboratory good practice: wear suitable gloves, eye protection and a lab coat, work with adequate ventilation, and avoid dust, contact and ingestion. Store in a tightly closed container in a cool, dry, well-ventilated place away from incompatible materials. Always consult the current Safety Data Sheet before use, as it is intended for laboratory and manufacturing use only and not for medicinal or household purposes.
How is N-(4-Iodo-2-methoxypyridin-3-yl)pivalamide packed, shipped and exported?
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It is packed in clean, well-sealed containers appropriate to the order quantity, with full labelling and documentation. As a global supplier and exporter, Tech Serve Solutions arranges export-compliant packaging and shipping with the relevant transport and customs paperwork to destinations worldwide.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, packaging and destination, and our team will respond with availability, lead time, specification and a formal quotation. Samples can be arranged for evaluation where appropriate.
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