N-(4-Chloro-3-iodo-pyridin-2-yl)-2,2-dimethyl-propionamide
N-(4-Chloro-3-iodo-pyridin-2-yl)-2,2-dimethyl-propionamide (CAS 898561-61-0; C10H12ClIN2O; molar mass 338.57 g/mol) is a halogenated pyridine building block bearing a pivalamide group at the 2-position with chloro and iodo substituents at the 4- and 3-positions. The orthogonal halogens and the directing amide make it a versatile intermediate for regioselective cross-coupling and functionalisation in pharmaceutical and fine-chemical synthesis. Tech Serve Solutions supplies it as a research-grade building block to laboratory and process chemists worldwide.
- Synonyms
- N-(4-Chloro-3-iodo-pyridin-2-yl)-2,2-dimethyl-propionamideN-(4-Chloro-3-iodopyridin-2-yl)pivalamideN-(4-Chloro-3-iodo-2-pyridinyl)-2,2-dimethylpropanamide2,2-Dimethyl-N-(4-chloro-3-iodopyridin-2-yl)propanamideCAS 898561-61-0
Heterocyclic building block
Serves as a substituted pyridine scaffold in the construction of more elaborate heterocyclic systems. The defined substitution pattern allows controlled elaboration of the pyridine ring in multi-step synthesis.
Cross-coupling intermediate
The carbon-iodine and carbon-chlorine bonds offer differentiated reactivity for palladium- and copper-catalysed cross-coupling, with the more reactive iodide typically engaging first. This supports sequential, regioselective carbon-carbon and carbon-heteroatom bond formation.
Pharmaceutical and agrochemical research
Used as a halogenated heterocyclic intermediate in medicinal-chemistry and agrochemical discovery programmes. It is a synthetic precursor rather than an active ingredient.
Directed functionalisation
The 2,2-dimethylpropionamide (pivalamide) acts as a robust, sterically hindered amide that can direct metalation and protect the ring nitrogen substituent during subsequent transformations.
| Molecular weight | 338.57 |
|---|---|
| Empirical formula | C10H12ClIN2O |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(4-Chloro-3-iodo-pyridin-2-yl)-2,2-dimethyl-propionamide used for?
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It is used as a halogenated pyridine building block in chemical synthesis. The orthogonal iodo and chloro groups and the pivalamide make it suitable for regioselective cross-coupling and directed functionalisation when building pharmaceutical and fine-chemical intermediates. It is a synthetic precursor, not a finished active ingredient.
What is the CAS number and molecular formula of N-(4-Chloro-3-iodo-pyridin-2-yl)-2,2-dimethyl-propionamide?
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Its CAS number is 898561-61-0 and its molecular formula is C10H12ClIN2O (Hill notation), with a molecular weight of 338.57 g/mol.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound as a research- and technical-grade building block for synthesis. We do not represent it as USP, BP or EP pharmacopoeial grade. A current Certificate of Analysis stating the actual assay and batch specification is provided with each consignment on request.
How should this compound be handled and stored?
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Handle as a research chemical using good laboratory practice: work in a fume hood, wear suitable gloves, eye protection and a lab coat, and avoid dust, contact and inhalation. Store tightly closed in a cool, dry, well-ventilated place away from incompatible materials. Always consult the current Safety Data Sheet before use; we supply the SDS with every order.
How is N-(4-Chloro-3-iodo-pyridin-2-yl)-2,2-dimethyl-propionamide packed, shipped and exported?
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It is packed in sealed, labelled containers appropriate to the order quantity, from gram research quantities to larger volumes, with packaging selected to protect the material in transit. As an established exporter since 1998, Tech Serve Solutions arranges compliant international documentation and shipping, with each consignment accompanied by a Certificate of Analysis and Safety Data Sheet.
How do I request a sample or quote?
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Contact Tech Serve Solutions with the product name or CAS number 898561-61-0, your required quantity and destination, and we will respond with availability, lead time and a formal quotation. Samples can be discussed for evaluation, subject to availability.
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