N-(3-Formyl-2-pyridinyl)-2,2-dimethylpropanamide
N-(3-Formyl-2-pyridinyl)-2,2-dimethylpropanamide (CAS 86847-64-5; C11H14N2O2; molar mass 206.24 g/mol) is a functionalised pyridine building block that combines an aldehyde at the 3-position with a 2,2-dimethylpropanamide (pivalamide) group on the adjacent ring nitrogen-bearing carbon. Supplied as a research-grade reagent of 97% assay, it serves chiefly as a synthetic intermediate in chemical synthesis, notably as a reactant for the preparation of disubstituted azaindolines and related heterocyclic scaffolds.
- IUPAC
- N-(3-Formylpyridin-2-yl)-2,2-dimethylpropanamide,N-(3-Formylpyridin-2-yl)-2,2-dimethylpropionamide
- Synonyms
- N-(3-Formyl-2-pyridinyl)-2,2-dimethylpropanamideN-(3-Formylpyridin-2-yl)-2,2-dimethylpropanamideN-(3-Formylpyridin-2-yl)-2,2-dimethylpropionamideN-(3-Formylpyridin-2-yl)pivalamide2,2-Dimethyl-N-(3-formylpyridin-2-yl)propanamide
Synthesis of disubstituted azaindolines
Documented as a reactant for the preparation of disubstituted azaindolines, where the 3-formyl group and the adjacent pivalamide nitrogen enable ring closure onto the pyridine core.
Heterocyclic building block
Used as a pyridine-based building block in chemical synthesis, providing a pre-functionalised scaffold for constructing fused and substituted nitrogen heterocycles.
Aldehyde for further functionalisation
The reactive 3-carbaldehyde supports common carbonyl transformations such as reductive amination, condensation and olefination, allowing further elaboration of the pyridine ring.
Protected/activated amine handle
The 2,2-dimethylpropanamide (pivalamide) group acts as a robust amide functionality on the ring, useful where a stable, sterically hindered acyl group is required during multi-step sequences.
Research and discovery chemistry
Suited to medicinal-chemistry and process-research laboratories developing pyridine and azaindoline-type intermediates. Supplied for research and manufacturing use, not for clinical or consumer application.
| Molecular weight | 206.24 |
|---|---|
| Empirical formula | C11H14N2O2 |
| Assay | 97%97% |
| Application | Reactant for:• Preparation of disubstituted azaindolines1 |
Hazard statements
- H315Causes skin irritation
- H317May cause an allergic skin reaction
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38-43 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(3-Formyl-2-pyridinyl)-2,2-dimethylpropanamide used for?
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It is used primarily as a synthetic building block and reactant in chemical synthesis. Its best-documented application is the preparation of disubstituted azaindolines, and the reactive 3-formyl group makes it a versatile intermediate for further functionalisation of the pyridine ring.
What is the CAS number and molecular formula of N-(3-Formyl-2-pyridinyl)-2,2-dimethylpropanamide?
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The CAS number is 86847-64-5 and the empirical formula is C11H14N2O2 (Hill notation), corresponding to a molecular weight of 206.24 g/mol. The MDL number is MFCD01830170.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound as a research/reagent-grade material with a typical assay of 97%. We do not represent it as USP, BP or EP pharmacopoeial grade. A certificate of analysis is provided with each batch, and specifications can be confirmed against your requirements before despatch.
What are the safety and handling requirements?
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The product carries GHS07 with the signal word Warning. The hazard statements are H315 (causes skin irritation), H317 (may cause an allergic skin reaction), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Handle with gloves, eye and face protection and an N95-type dust mask, avoid dust formation, and work with adequate ventilation. Always consult the Safety Data Sheet before use.
How is it packed, shipped and exported?
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It is packed in tightly sealed, appropriately labelled containers with sizes selected to suit laboratory and bulk requirements. As a global supplier and exporter since 1998, Tech Serve Solutions arranges compliant international shipping with full documentation, including the Safety Data Sheet and certificate of analysis.
Is this a controlled or scheduled substance?
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The supplied data does not indicate any drug-control or scheduling status for this compound. It is offered as a research chemical and synthetic intermediate. It is classified WGK 3 (Germany) for water-hazard purposes, so handling and disposal should follow local environmental regulations.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, purity and destination, and our team will respond with availability, lead time and a formal quotation. Samples can be discussed for qualification, subject to availability and applicable shipping requirements.
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