N-(3-Aminopropyl)piperidine
N-(3-Aminopropyl)piperidine (CAS 3529-08-6, C8H18N2, MW 142.24) is a versatile chemical building block. It serves as a crucial reactant in the synthesis of various complex molecules, including novel therapeutic agents targeting serious diseases. Its primary applications lie in advanced chemical synthesis, particularly for heterocyclic compounds and substituted piperidines with potential pharmaceutical relevance.
- IUPAC
- 3-Piperidinopropylamine
- Synonyms
- 3-Piperidinopropylamine
Synthesis of Therapeutic Agents
Serves as a key reactant in the development of compounds that inhibit critical biological targets such as <i>Botulinum</i> neurotoxin serotype A light chain, <i>P. falciparum</i> Malaria, and <i>Ebola</i> filovirus. It is also used in creating membrane-targeting antibiotics and antagonists for histamine H3 receptors.
Development of Receptor Antagonists
Incorporated into the synthesis of 5-HT3A receptor antagonists, which are important targets in the pharmaceutical industry for various therapeutic applications.
Anticancer and Antimalarial Research
Used in the preparation of Berberine derivatives designed for stabilizing G-quadruplex DNA and down-regulating the oncogene c-myc. Also employed to introduce basic side chains into cryptolepine scaffolds for antimalarial research.
| Molecular weight | 142.24 |
|---|---|
| Empirical formula | C8H18N2 |
| Assay | 95% |
| Density | 0.895 g/mL at 25 °C |
| Refractive index | n20/D 1.476 |
| Application | Reactant for synthesis of:• A chemotype that inhibits Botulinum neurotoxin serotype A light chain, P. falciparum Malaria, and Ebola filovirus1• Membrane targeting antibiotics2• 5-HT3A receptor antagonists3• Histamine H3 antagonists4• Berberine derivatives for stabilization of G-quadruplex DNA and down regulation of oncogene c-myc5Reactant for incorporation of basic side chains into cryptolepine scaffold for antimalarial activity6 |
Hazard statements
- H302Harmful if swallowed
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 82 °C / 179.6 °F |
| Transport (UN / ADR) | UN 2735PSN1 8 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 22-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(3-Aminopropyl)piperidine used for?
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N-(3-Aminopropyl)piperidine (CAS 3529-08-6) is primarily used as a reactant in chemical synthesis for developing therapeutic agents, including those targeting botulinum neurotoxin, malaria, Ebola virus, and various receptor antagonists.
What are the CAS number and formula for N-(3-Aminopropyl)piperidine?
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The CAS number for N-(3-Aminopropyl)piperidine is 3529-08-6, and its empirical formula is C8H18N2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N-(3-Aminopropyl)piperidine with an assay of 95%. This product is intended for research and development purposes and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should N-(3-Aminopropyl)piperidine be handled safely?
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N-(3-Aminopropyl)piperidine is classified as Danger. It is harmful if swallowed and causes severe skin burns and eye damage (H302-H314). Handle with appropriate personal protective equipment, including gloves, goggles, face shields, and suitable respiratory protection. Ensure adequate ventilation and refer to the Safety Data Sheet for detailed handling procedures.
Is N-(3-Aminopropyl)piperidine shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including N-(3-Aminopropyl)piperidine.
How can I request a sample or quote for N-(3-Aminopropyl)piperidine?
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To request a sample or quote for N-(3-Aminopropyl)piperidine, please contact our sales department through the website or by phone.
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