N-(3-Aminopropyl)-2-pyrrolidinone
N-(3-Aminopropyl)-2-pyrrolidinone (CAS 7663-77-6; C7H14N2O; molar mass 142.20 g/mol) is a bifunctional liquid heterocyclic building block combining a 2-pyrrolidinone (lactam) ring with a pendant primary amine on a propyl chain. This dual reactivity makes it a versatile intermediate in chemical synthesis, where the amine supports amidation, alkylation and reductive amination. It is also used as a derivatising and reference reagent in analytical work, including the gas-chromatographic determination of polyamines. Tech Serve Solutions supplies it to research and industrial users worldwide.
- Synonyms
- N-(3-Aminopropyl)-2-pyrrolidinone1-(3-Aminopropyl)-2-pyrrolidinone1-(3-Aminopropyl)pyrrolidin-2-one1-(3-Aminopropyl)-2-pyrrolidoneN-(3-Aminopropyl)pyrrolidin-2-one3-(2-Oxo-1-pyrrolidinyl)propylamineCAS 7663-77-6
Heterocyclic building block for synthesis
Serves as a C4–C8 pyrrolidinone scaffold bearing a reactive primary amine, enabling amide bond formation, alkylation and reductive amination. It is a convenient handle for building more complex nitrogen-containing molecules and functionalised lactams.
Pharmaceutical and fine-chemical intermediate
The combined lactam and aminopropyl functionality is useful in preparing pharmaceutical intermediates and speciality fine chemicals. Specific downstream routes depend on the customer's process and are not represented here.
Polyamine analysis reagent
Reported in the simultaneous determination of total polyamines and three of their non-alpha-amino-acid metabolites in urine by capillary gas chromatography with nitrogen–phosphorus detection. This makes it relevant to analytical and bioanalytical method development.
Ligand and chelation studies
As a molecule presenting both an amide carbonyl and a primary amine, it can act as a multidentate donor in coordination and chelation studies. Suitability for a given metal system should be confirmed experimentally.
Research and reference standard use
Supplied as a defined organic compound for laboratory research, derivatisation chemistry and use as a reference material in method development. Typical purity is consistent with reagent-grade material containing a small residual 2-pyrrolidinone content.
| Molecular weight | 142.20 |
|---|---|
| Empirical formula | C7H14N2O |
| Boiling point | 120-123 °C/1 mmHg(lit.) |
| Density | 1.014 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.5(lit.) |
| Impurities tested | 2% 2-pyrrolidinone |
| Application | N-(3-Aminopropyl)-2-pyrrolidinone was used in the simultaneous determination of total polyamines and three of their non−α− amino acid metabolites in urine by capillary gas-chromatographic method with nitrogen-phosphorus detection1. |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 3267 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(3-Aminopropyl)-2-pyrrolidinone used for?
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It is mainly used as a heterocyclic building block and intermediate in chemical synthesis, where its primary amine supports amidation, alkylation and reductive amination. It is also used as a reagent in analytical chemistry, including the gas-chromatographic determination of polyamines and their metabolites. It is a laboratory and industrial chemical, not a finished consumer product.
What is the CAS number and molecular formula of N-(3-Aminopropyl)-2-pyrrolidinone?
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The CAS number is 7663-77-6 and the molecular formula is C7H14N2O, with a molecular weight of 142.20 g/mol. Related identifiers include EC number 231-632-7 and MDL number MFCD00003201. It is a clear liquid with a density of about 1.014 g/mL at 25 °C and a boiling point of 120–123 °C at 1 mmHg.
What grade and purity does Tech Serve Solutions supply?
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We supply N-(3-Aminopropyl)-2-pyrrolidinone as a technical/research-grade reagent suitable for synthesis and laboratory use; material of this type typically contains around 2% residual 2-pyrrolidinone. We do not represent it as USP, BP or EP pharmacopoeial grade. A current specification and certificate of analysis can be provided on request so you can confirm suitability for your application.
What are the safety and handling requirements?
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It is classified under GHS as corrosive with the signal word Danger and hazard statement H314 (causes severe skin burns and eye damage). Handle it only with suitable protection, including chemical-resistant gloves, goggles or a face shield and, where exposure is possible, an ABEK-type respirator. Follow the precautionary measures P280, P305+P351+P338 and P310, and consult the Safety Data Sheet before use. It is also classified WGK 3 (highly water-hazardous), so prevent release to drains and the environment.
How is N-(3-Aminopropyl)-2-pyrrolidinone packed, shipped and exported?
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It is packed in tightly sealed, compatible containers appropriate to the order quantity and labelled to GHS requirements. As a corrosive liquid it is consigned as dangerous goods under UN 3267, Class 8, Packing Group II, with transport documentation prepared accordingly. Tech Serve Solutions exports worldwide and can align packaging and paperwork with your destination and freight requirements.
How do I request a sample or quote?
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Contact Tech Serve Solutions with the product name, CAS number 7663-77-6, the quantity you need and your delivery destination. We will confirm current availability, specification and lead time, and provide a formal quotation. Samples can be arranged where appropriate to support your evaluation and qualification.
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