N-(2-Chloro-6-(trimethylsilyl)pyridin-3-yl)pivalamide
N-(2-Chloro-6-(trimethylsilyl)pyridin-3-yl)pivalamide (CAS 1142191-74-9, C13H21ClN2OSi, molar mass 284.86 g/mol) is a functionalised pyridine building block. It combines a 2-chloro substituent, a 6-trimethylsilyl group and a pivaloyl amide on the pyridine ring, giving multiple orthogonal handles for further elaboration. Tech Serve Solutions supplies it as a research-grade organosilicon intermediate for pharmaceutical, agrochemical and fine-chemical synthesis, principally in directed metalation and cross-coupling routes.
- Synonyms
- N-(2-Chloro-6-(trimethylsilyl)pyridin-3-yl)pivalamideN-[2-chloro-6-(trimethylsilyl)pyridin-3-yl]-2,2-dimethylpropanamideN-(2-chloro-6-(trimethylsilyl)pyridin-3-yl)-2,2-dimethylpropanamide2,2-dimethyl-N-[2-chloro-6-(trimethylsilyl)pyridin-3-yl]propanamideCAS 1142191-74-9
Pharmaceutical intermediate
Used as a heterocyclic building block in medicinal-chemistry and pharmaceutical research, where the substituted pyridine scaffold is carried forward into more complex target molecules.
Cross-coupling substrate
The 2-chloro group provides a reactive site for palladium- or nickel-catalysed cross-coupling, allowing the introduction of aryl, heteroaryl and other carbon substituents onto the pyridine ring.
Organosilicon handle
The trimethylsilyl group at the 6-position serves as a versatile organosilicon functionality that can be retained, exchanged or removed during downstream synthesis.
Directed functionalisation
The pivaloyl amide is a well-established amide directing and protecting group, supporting regioselective metalation and controlled elaboration of the pyridine core.
Agrochemical and fine-chemical synthesis
As a halogenated heterocyclic building block, it is of interest in agrochemical discovery and broader fine-chemical research programmes that require substituted pyridine intermediates.
| Molecular weight | 284.86 |
|---|---|
| Empirical formula | C13H21ClN2OSi |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(2-Chloro-6-(trimethylsilyl)pyridin-3-yl)pivalamide used for?
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It is used as a research building block in pharmaceutical, agrochemical and fine-chemical synthesis. The chloro, trimethylsilyl and pivalamide groups give orthogonal handles for cross-coupling, directed metalation and further functionalisation of the pyridine ring.
What is the CAS number and molecular formula of N-(2-Chloro-6-(trimethylsilyl)pyridin-3-yl)pivalamide?
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Its CAS number is 1142191-74-9 and its empirical formula is C13H21ClN2OSi (Hill notation), with a molecular weight of 284.86 g/mol.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound as a research/technical-grade building block for synthesis and laboratory use. We do not represent it as USP, BP or EP pharmacopoeial grade. A current specification and certificate of analysis can be provided on request with each lot.
How should N-(2-Chloro-6-(trimethylsilyl)pyridin-3-yl)pivalamide be handled and stored?
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Handle it as a research chemical using good laboratory practice: wear suitable gloves, eye protection and a lab coat, work with adequate ventilation, and avoid dust, contact and ingestion. Store in a tightly closed container in a cool, dry, well-ventilated place away from incompatible materials. Always consult the current Safety Data Sheet before use.
How is N-(2-Chloro-6-(trimethylsilyl)pyridin-3-yl)pivalamide packed, shipped and exported?
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It is packed in appropriately sealed, labelled laboratory containers sized to the order, from gram to larger research quantities. Tech Serve Solutions exports worldwide with full documentation and a Safety Data Sheet, using compliant transport and packaging arrangements suited to the destination.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, intended purity and destination, and our team will confirm availability, specification and lead time. We can arrange samples and formal quotations for research and commercial requirements.
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