N-(2-Chloro-6-cyanopyridin-3-yl)pivalamide
N-(2-Chloro-6-cyanopyridin-3-yl)pivalamide (CAS 1142191-90-9; molecular formula C11H12ClN3O; molar mass 237.69 g/mol) is a multifunctional pyridine building block. The molecule combines a chloro substituent, a nitrile (cyano) group and a pivaloyl-protected ring amine on a single electron-poor pyridine core, giving several orthogonal handles for further elaboration. It is used principally as an intermediate in pharmaceutical, medicinal-chemistry and fine-chemical synthesis. Tech Serve Solutions supplies it as a research-grade building block to laboratories and manufacturers worldwide.
- Synonyms
- N-(2-Chloro-6-cyanopyridin-3-yl)pivalamideN-(2-chloro-6-cyanopyridin-3-yl)-2,2-dimethylpropanamideN-[2-chloro-6-cyano-3-pyridinyl]-2,2-dimethylpropanamide2,2-dimethyl-N-(2-chloro-6-cyanopyridin-3-yl)propanamideCAS 1142191-90-9
Pharmaceutical and medicinal-chemistry intermediate
Serves as a halogenated heterocyclic building block in the synthesis of pharmaceutical candidates and active intermediates. The cyano-substituted chloropyridine scaffold is a common motif accessed during discovery and process chemistry.
Cross-coupling and substitution chemistry
The ring chlorine on the electron-poor pyridine provides a reactive site for palladium-catalysed cross-coupling and nucleophilic aromatic substitution, allowing aryl, amino and other groups to be introduced as the molecule is built up.
Nitrile handle for further transformation
The cyano group is a versatile functional handle that can be hydrolysed, reduced or otherwise converted, giving access to carboxamides, carboxylic acids, aminomethyl groups and nitrogen heterocycles such as tetrazoles and amidines.
Protected aminopyridine for selective synthesis
The pivalamide masks the ring amine as a robust, sterically hindered protecting group, enabling selective reactions elsewhere on the molecule before deprotection in multi-step routes.
Reference and research material
Applied in laboratory research and method development where a defined, single-compound chloropyridine building block is required. Supplied for research and manufacturing use, not for direct human or veterinary administration.
| Molecular weight | 237.69 |
|---|---|
| Empirical formula | C11H12ClN3O |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(2-Chloro-6-cyanopyridin-3-yl)pivalamide used for?
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It is used mainly as a building block and intermediate in pharmaceutical, medicinal-chemistry and fine-chemical synthesis. Its chloropyridine core, nitrile group and pivalamide-protected amine provide multiple reactive handles for cross-coupling, nucleophilic substitution and selective functional-group chemistry when building more complex heterocyclic molecules.
What is the CAS number and molecular formula of N-(2-Chloro-6-cyanopyridin-3-yl)pivalamide?
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Its CAS number is 1142191-90-9 and its molecular formula is C11H12ClN3O (Hill notation), corresponding to a molecular weight of 237.69 g/mol.
What grade and purity does Tech Serve Solutions supply?
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We supply this compound as a research and technical-grade building block for synthesis and laboratory use. We do not represent it as USP, BP or EP pharmacopoeial grade. A current specification and certificate of analysis, including the assay for your batch, are provided on request so you can confirm suitability before purchase.
How should N-(2-Chloro-6-cyanopyridin-3-yl)pivalamide be handled and stored?
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A full GHS hazard classification is not specified in our data, so handle it as a research chemical of unknown hazard using good laboratory practice. Wear suitable gloves, eye protection and a lab coat, work with adequate ventilation, and avoid dust, skin and eye contact and ingestion. Store in a tightly closed container in a cool, dry, well-ventilated place away from incompatible materials, and consult the Safety Data Sheet supplied with the product before use.
How is N-(2-Chloro-6-cyanopyridin-3-yl)pivalamide packed, shipped and exported?
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It is packed in sealed, labelled containers sized from gram quantities to bulk research scale, with packaging selected to protect the material in transit. As a specialist exporter since 1998, Tech Serve Solutions arranges compliant worldwide shipping with full documentation, including the certificate of analysis and Safety Data Sheet. Pack sizes and shipping terms are confirmed at the quotation stage.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, grade and delivery destination, quoting product 114943 and CAS 1142191-90-9. We will respond with availability, specification, lead time and a formal quotation, and can arrange a sample where appropriate.
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