N-(2-Chloro-6-(3-hydroxyprop-1-ynyl)pyridin-3-yl)pivalamide
N-(2-Chloro-6-(3-hydroxyprop-1-ynyl)pyridin-3-yl)pivalamide (CAS 1142192-04-8; molecular formula C13H15ClN2O2; molar mass 266.72 g/mol) is a multifunctional pyridine building block. The molecule combines a chloropyridine core, a pivalamide-protected amine and a hydroxypropynyl (propargyl alcohol) side chain, giving several orthogonal handles for further elaboration. It is used principally as an intermediate and building block in pharmaceutical, medicinal-chemistry and fine-chemical synthesis. Tech Serve Solutions supplies it as a research-grade building block to laboratories and manufacturers worldwide.
- Synonyms
- N-(2-Chloro-6-(3-hydroxyprop-1-ynyl)pyridin-3-yl)pivalamideN-[2-chloro-6-(3-hydroxyprop-1-yn-1-yl)pyridin-3-yl]-2,2-dimethylpropanamideN-[2-chloro-6-(3-hydroxy-1-propynyl)-3-pyridinyl]-2,2-dimethylpropanamide2,2-dimethyl-N-[2-chloro-6-(3-hydroxyprop-1-ynyl)pyridin-3-yl]propanamideCAS 1142192-04-8
Pharmaceutical and medicinal-chemistry intermediate
Serves as a halogenated heterocyclic building block in the synthesis of pharmaceutical candidates and active intermediates. The chloropyridine scaffold is a common motif accessed during discovery and process chemistry.
Cross-coupling and functionalisation substrate
The chloro substituent on the electron-poor pyridine ring offers a site for palladium- or copper-catalysed cross-coupling, allowing the introduction of aryl, heteroaryl, amino and other groups to extend molecular complexity.
Alkyne handle for click and further chemistry
The terminal hydroxyprop-1-ynyl (propargyl alcohol) group provides an alkyne for copper-catalysed azide-alkyne cycloaddition and related transformations, as well as a primary hydroxyl for derivatisation.
Protected aminopyridine for selective synthesis
The pivalamide masks the ring amine as a robust, sterically hindered protecting group, enabling selective reactions elsewhere on the molecule before deprotection.
Reference and research material
Used in laboratory research and method development where a defined, single-compound chloropyridine building block is required.
| Molecular weight | 266.72 |
|---|---|
| Empirical formula | C13H15ClN2O2 |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(2-Chloro-6-(3-hydroxyprop-1-ynyl)pyridin-3-yl)pivalamide used for?
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It is used mainly as a building block and intermediate in pharmaceutical, medicinal-chemistry and fine-chemical synthesis. Its chloropyridine core, protected amine and propargyl-alcohol side chain provide multiple reactive handles for cross-coupling, click chemistry and selective functionalisation.
What is the CAS number and molecular formula of N-(2-Chloro-6-(3-hydroxyprop-1-ynyl)pyridin-3-yl)pivalamide?
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Its CAS number is 1142192-04-8 and its molecular formula is C13H15ClN2O2 (Hill notation), corresponding to a molecular weight of 266.72 g/mol.
What grade and purity does Tech Serve Solutions supply?
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We supply this compound as a research and technical-grade building block for synthesis and laboratory use. We do not represent it as USP, BP or EP pharmacopoeial grade. A current specification and certificate of analysis, including the assay for your batch, are provided on request.
How should N-(2-Chloro-6-(3-hydroxyprop-1-ynyl)pyridin-3-yl)pivalamide be handled and stored?
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Handle it as a research chemical using good laboratory practice: wear suitable gloves, eye protection and a lab coat, work with adequate ventilation, and avoid dust, contact and ingestion. Store in a tightly closed container in a cool, dry, well-ventilated place. Consult the Safety Data Sheet supplied with the product before use; full GHS classification is provided on the SDS.
How is N-(2-Chloro-6-(3-hydroxyprop-1-ynyl)pyridin-3-yl)pivalamide packed, shipped and exported?
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It is packed in laboratory- and bulk-appropriate containers, sealed, labelled and protected for transit. Tech Serve Solutions ships and exports worldwide with the relevant documentation, including the certificate of analysis and Safety Data Sheet. Pack sizes and shipping terms are confirmed at the quotation stage.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, grade and delivery destination, quoting product 114939 and CAS 1142192-04-8. We will respond with availability, specification, lead time and a quotation, and can arrange a sample where appropriate.
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